Results 71 to 80 of about 2,195,151 (316)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 1958 It is possible to draw certain parallels between the West\u27s present predicament and similar periods of radical change and the dislocation of values, and so to suggest that this sort of thing has happened before, that man has always come our of such ...
Bloom, Robert L. +6 more
core
Effect of Query Formation on Web Search Engine Results
, 2013 Query in a search engine is generally based on natural language. A query can be expressed in more than one way without changing its meaning as it depends on thinking of human being at a particular moment.
Bisht, Ila Pant, Bisht, Raj Kishor
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Contextual Effects on Metaphor Comprehension: Experiment and Simulation [PDF]
, 2003 This paper presents a computational model of referential metaphor comprehension. This model is designed on top of Latent Semantic Analysis (LSA), a model of the representation of word and text meanings.
Bianco, Maryse, Lemaire, Benoit
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
BMC Public HealthObjective Loneliness is a growing mental health challenge among youth specially who are residing in urban areas. Factors that might help them combat loneliness need to be investigated.
Raina Chhajer +2 more
doaj +1 more source
Idei, 2020 I would like to present a specific kind of social structure – that of a community of about 50 Bulgarians who live in the St. Georgi Zografski monastery in the monastic republic of Mount Athos (Holy Mountain) within the territory of the Republic of Greece.
Mitko Momov
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Analysis of the Elements of Logotherapy in Attar Neyshaburi's Mantiq al-Tayr [PDF]
ادبیات عرفانیThe Mantiq al-Tayr, as a seminal work of mystical literature, symbolizes humanity’s quest for meaning and truth. To To explore the multifaceted nature of this text, this study examines the relationship between the theory of logotherapy and Mantiq al-Tayr.
Farideh Davoudimoghadam
doaj +1 more source