Results 61 to 70 of about 2,195,151 (316)
Plug-in to fear: game biosensors and negative physiological responses to music [PDF]
, 2015 The games industry is beginning to embark on an ambitious journey into the world of biometric gaming in search of more exciting and immersive gaming experiences.
Mitchell, Helen
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Zum Bildungspotenzial biblischer Texte
Österreichisches Religionspädagogisches Forum, 2017 Biblical education as a holistic process goes far beyond biblical learning. It must be understood as a lifelong process, in which both biblical texts and their understanders operate appropriating their counterpart in a dialogical way. – Neither does the
Theis, Joachim
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Recognizable Goodness”: A Response to Beversluis’ Understanding of God’s Goodness [PDF]
, 2016 In her rebuttal to John Beversluis’ C. S. Lewis and the Search for Rational Religion, Emily McCarty makes the following arguments. Lewis maintains throughout these three works that God’s goodness is recognizable. In The Problem of Pain, what seems unlike
McCarty, Emily
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Yaşamın Anlamı Konusuna Kuramsal ve Psikometrik Çalışmalar Açısından Bir Bakış
Ankara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2012 Bu araştırmanın amacı ülkemizde araştırmalara yeterince konu olmamış yaşamın anlamı konusuna felsefi ve psikolojik bir perspektiften bakarak, konuya ilişkin kuramsal bir zemin sunmak, yaşamını anlamlı bulmanın temel bir psikolojik gereksinim olduğuna ...
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