Results 41 to 50 of about 198,614 (250)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Yaşamın Anlamı Konusuna Kuramsal ve Psikometrik Çalışmalar Açısından Bir Bakış
Ankara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2012 Bu araştırmanın amacı ülkemizde araştırmalara yeterince konu olmamış yaşamın anlamı konusuna felsefi ve psikolojik bir perspektiften bakarak, konuya ilişkin kuramsal bir zemin sunmak, yaşamını anlamlı bulmanın temel bir psikolojik gereksinim olduğuna ...
Sevgi SEZER
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Analysis of the Elements of Logotherapy in Attar Neyshaburi's Mantiq al-Tayr [PDF]
ادبیات عرفانیThe Mantiq al-Tayr, as a seminal work of mystical literature, symbolizes humanity’s quest for meaning and truth. To To explore the multifaceted nature of this text, this study examines the relationship between the theory of logotherapy and Mantiq al-Tayr.
Farideh Davoudimoghadam
doaj +1 more source
Idei, 2020 I would like to present a specific kind of social structure – that of a community of about 50 Bulgarians who live in the St. Georgi Zografski monastery in the monastic republic of Mount Athos (Holy Mountain) within the territory of the Republic of Greece.
Mitko Momov
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source