Results 111 to 120 of about 31,005 (332)

Keyword-Based Delegable Proofs of Storage

open access: yes, 2018
Cloud users (clients) with limited storage capacity at their end can outsource bulk data to the cloud storage server. A client can later access her data by downloading the required data files.
C Wang   +11 more
core   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

open access: yesAdvanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang   +8 more
wiley   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

open access: yesAdvanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong   +11 more
wiley   +1 more source

Exploiting Hidden Information Leakages in Backward Privacyfor Dynamic Searchable Symmetric Encryption [PDF]

open access: green, 2023
Hyundo Yoon   +4 more
openalex   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

open access: yesAdvanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan   +17 more
wiley   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

open access: yesAdvanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li   +13 more
wiley   +1 more source

Experimental Joint Estimation of Phase and Phase Diffusion Via Deterministic Bell Measurements

open access: yesAdvanced Science, EarlyView.
This work employs Bell measurement, a form of entangling measurement, to estimate both the phase and its fluctuations in an optical interferometer. By incorporating a novel quantum effect at the measurement stage, the proposed method achieves the ultimate precision limit and demonstrates the significant potential of entangling measurements in multi ...
Ben Wang   +4 more
wiley   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

open access: yesAdvanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao   +14 more
wiley   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He   +5 more
wiley   +1 more source

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