Results 121 to 130 of about 658,036 (261)

Growth mindset and learning engagement among Chinese college students: a chain mediation model and gender difference. [PDF]

BMC Psychol
Pan Y, Huang M, Lou J.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Using Artificial Intelligence to Enhance Evidence Search and Synthesis. [PDF]

Am J Nurs
Bell S, Ackerman M, Buck J, Frueh A, Maitland J, Piotrowski K, Sokol M, Tussing TE, Zellefrow C, McNett M.   +9 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Graphical vs. nongraphical displays: which one is the best labeling system for laboratory searching task?

, 2018
Graphical displays are known to improve the process of obtaining information because it can be easily comprehended. It also can be recognized faster and more precisely compared to nongraphical (i.e. alphanumerical) displays. However, it is unknown if the
Adnan, Ammar, Mohd Zamri, Muhamad Zul Asraf, Abdul Hamid, Abd. Malek, Radin Umar, Radin Zaid, Samuel, Siby, Shaffiar, Norhashimah   +5 more
core  

Information Specialist Roles in the Era of Large Language Models: Prompting Continued Professional Development. [PDF]

Campbell Syst Rev
O'Keefe H, Eastaugh CH, Wallace SA, Beyer FR.   +3 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Comprehensive literature searching in the health sciences

This research guide is designed to support users in conducting comprehensive searches of scholarly literature, particularly within the health sciences. It is organized around a step-by-step approach to developing and executing a rigorous search strategy:
Cottais, Camille, Farrell, Peter, Langlois, Nigèle   +2 more
core