Results 121 to 130 of about 808,219 (241)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Urban gardens foster year-round activity of bumble bee queens. [PDF]

Ecology
Finn SR, Erickson E, Crone EE.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

3D Range Searching Using Chain Decomposition

, 2017
We propose the first data structure based on untangled monotonic chains for or- thogonal range searching in 3-dimensional space. The idea is an extension of the 2-dimensional chain partition algorithm proposed by Arroyuelo et al.
Guo, Yingda
core  

Deriving and applying facet views of the dewey decimal classification scheme to enhance subject searching in library OPACs [PDF]

Classification is a fundamental tool in the organisation of any library collection for effective information retrieval. Several classifications exist, yet the pioneering Dewey Decimal Classification (DDC) still constitutes the most widely used scheme and
Tinker, Amanda
core   +1 more source

Who Eats Whom? A global food web derived from citizen science. [PDF]

PLoS Biol
Allf BC, Mallavarapu A, Kikuchi DW, Vasudeva N, Dunn RR.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

How the Camel's Back Breaks: A Scoping Review of Cumulative Occupational Distress and the Conceptual Absence of Micro-Trauma in Nursing. [PDF]

Nurs Rep
Dale M, Chapman M, West C.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Reproducible study identification and selection in systematic reviews: barriers and paths forward. [PDF]

BMJ Open
Lin L, Xing X, Wu C, Chen Y, Tong J, McClelland DJ, Chen Z.   +6 more
europepmc   +1 more source