Results 121 to 130 of about 40,308 (282)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evaluation of functional mobility of patients with stroke sequela after treatment in hydrotherapy pool using the Timed Up and Go Test [PDF]

Einstein (São Paulo), 2011
Objective: To evaluate the functional mobility of patients with strokeover 12 sessions of hydrotherapy. Methods: Ten stroke patients agedbetween 5 and 85 years were evaluated by means of the Timed Up andGo test, which contains some items, such as balance,
Daniel Gonçalves dos Santos, Andréa Sanches Navarro Pegoraro, Carolina Vilela Abrantes, Fabio Jakaitis, Silvia Gusman, Simone Cristina Bifulco   +5 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Effects of Seated Whole-Body Vibration on Spinal Stability Control

, 2008
Low back disorders and their prevention is of great importance for companies and their employees. Whole-body vibration is a risk factor for low back disorders, but the neuromuscular, biomechanical, and/or physiological mechanisms responsible for this ...
Slota, Gregory P.
core  

Induction of an anti-tumor immune response by sonodynamic therapy, combining 5-aminolevulinic acid and high-intensity focused ultrasound using the trigger pulse sonication

WFUMB Ultrasound Open
Ultrasound-based cancer therapies offer non-invasive treatment options for deep-seated tumors, yet their clinical application is often limited by safety concerns.
Tohru Satoh, Rui Tada, Taiki Yamaguchi, Yoko Endo-Takahashi, Takashi Kanno, Mai Hayakawa, Yoshiyuki Adachi, Yoichi Negishi, Jun Okamoto, Shin Yoshizawa, Ken Masamune   +10 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

An intelligent digital guide plate for visual inspection of seating and dynamic balance

Frontiers in Materials
The aim of the present study was to develop an intelligent digital planting guide plate to achieve precise positioning and dynamic balance of the guide plate with visual real-time monitoring. To achieve this, Mechanoluminescence (ML) materials (BaSi2O2N2: Eu2+, BSON) was innovatively incorporated into methyl methacrylate (MAA) resin, forming BM ...
Xiang-Zhe Zhao, Nai-Yu Shi, Qian Chen, Yue Xing, Yan-Zhu Guo, Ming-Zhu He, Fu-Xiang Song, Bin Liu   +7 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source