This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou +8 more
wiley +1 more source
The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases. [PDF]
Mosca S +4 more
europepmc +1 more source
PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma +12 more
wiley +1 more source
Integrated Whole-Exome and Transcriptome Sequencing Indicated Dysregulation of Cholesterol Metabolism in Eyelid Sebaceous Gland Carcinoma. [PDF]
Wang Y +6 more
europepmc +1 more source
UV-A Radiation Impairs Sebaceous-Gland-Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum-Like Lipid Composition. [PDF]
Dong W +5 more
europepmc +1 more source
The World's First Acne Dysbiosis-like Model of Human 3D Ex Vivo Sebaceous Gland Colonized with <i>Cutibacterium acnes</i> and <i>Staphylococcus epidermidis</i>. [PDF]
Forraz N +8 more
europepmc +1 more source
Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao +9 more
wiley +1 more source

