Results 101 to 110 of about 11,201 (278)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Rippled-pattern sebaceoma : A report of a lesion on the back with a review of the literature [PDF]

A 68-year-old Japanese man presented with a nodule that had been present for 5 to 6 years on the right side of the back. Physical examination revealed a dome-shaped, 12 X 13-mm, dark red nodule. It was excised with a 2 to 3-mm margin.
ANSAI, Shinichi, KIYOHARA, Takahiro, KUMAKIRI, Masanobu, KUWAHARA, Hiroaki, SAITOH, Atsuko   +4 more
core  

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Presacral Myelolipoma [PDF]

, 2014
Many reports have described adrenal myelolipomas but there have been only a few reports of extra-adrenal myelolipomas. We describe a 74-year-old woman who came to our observa- tion for MRI of the lumbar spine for typical lumbar back pain.
FALANGA, Giorgia, GAGLIARDO, Cesare, LA TONA, Giuseppe, LAGALLA, Roberto, LO CASTO, Antonio, MIDIRI, Massimo, SUTERA, Raffaello   +6 more
core   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Age outweighs race in survival of sebaceous gland carcinoma of the eyelid: A 21-year SEER database analysis

AJO International
Purpose: Sebaceous gland carcinomas (SC) are rare neoplasms arising from the eyelids’ sebaceous glands. Investigating racial disparities in their occurrence, management, and outcomes is crucial for enhancing patient care.
Said Yaseen, Ahmad Sermed Al Sakini, Sara Al-Banna, Alaa H. Ewida, Mohammad Hamad, Mahmoud M. Abu Tafesh, Leen Abu Rabi, Hashem Abu Serhan   +7 more
doaj   +1 more source

Ovarian teratoma in the mare: a review and two cases [PDF]

, 2010
A 4-year-old Belgian Warmblood mare suffering from pelvic flexure impaction was diagnosed with a teratoma of the left ovary. The enlarged ovary was identified several days after treatment of the impaction.
de Kruif, Aart, De Schauwer, Catharina, Ducatelle, Richard, Durie, Inge, Govaere, Jan, Hoogewijs, Maarten, Martens, Ann, Schauvliege, Stijn, Smits, Katrien, Vanhaesebrouck, Emilie, Vercauteren, Griet   +10 more
core  

Androgen receptor expression in metastatic adenocarcinoma in females favors a breast primary [PDF]

, 2006
Background The differential diagnosis of metastatic mammary adenocarcinoma and adenocarcinomas from other primary sites can be challenging, particularly in tumors that are poorly differentiated and negative for Estrogen/Progesterone receptors (ER/PR ...
Vinod B Shidham, Richard A Komorowski, Jinobya K Machhi, PA Wingo, SG Silverberg, O Kaufmann, BH Lee, AH Ormsby, FA Longatto, ML Wallace, JM Su, OA Lea, B Ilene, WR Miller, V Knenen-Boumeester, JJ Isola, RE Hall, S Liao, JA Ruizeveld de Winter, M Iwamura, GW Chodak, C Magi-Galluzzi, H Takeda, LP Pertschuk, S Chadha, R Kuhnel, K Horie, SB Kapadia, CY Fan, HC Hwang, C Cohen, SM Nasser, SN Agoff   +32 more
core   +2 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Pilomatrix carcinoma of the lacrimal caruncle: a case report. [PDF]

, 2020
A 45-year-old man presented with a 3-month history of a mass located in the caruncle of his right eye. An incisional biopsy had been performed one month prior by another specialist, and the histopathology report showed basal cell carcinoma.
Acıkalin, Arbil, Ciloglu, Emine, Harbiyeli, Ibrahim Inan, Ozcan, Altan A, Shields, Carol L   +4 more
core   +1 more source