Results 81 to 90 of about 11,201 (278)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease [PDF]

, 2010
While mammary Paget's disease (MPD) is clearly linked to breast cancer, the histogenesis of extramammary Paget's disease (EMPD) is controversial. Recently NY-BR-1, a differentiation antigen expressed in the breast and in skin adnexal structures was ...
Abbott, Anderson, Beer, Bianco, Brown, Chen, Crawford, Crocker, Fanning, Giger, Guarner, Jager, Jager, Jager, Kanitakis, Kinkor, Kohler, Kuan, Lau, Liegl, Lloyd, Marucci, Mehta, Nishie, Ogawa, Reich, Tanskanen, Theurillat, Theurillat, Toker, Urabe, Van Der Putte, Van Der Putte, Varga, Wilkinson, Williamson, Willman, Wolff   +37 more
core   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Muir-Torre syndrome is a predictor of gastric cancer (clinical observation)

Современная наука и инновации
Muir-Torre syndrome is a hereditary autosomal dominant syndrome that belongs to HNPCC (Lynch syndrome), being its subspecies. The disease is associated with a high risk of developing colorectal cancer, as well as other cancers of the gastrointestinal ...
Yu. A. Dykhno, Yu. V. Karacheva, Yu. Yu. Vinnik, V. S. Tsikh   +3 more
doaj   +1 more source

Clinical and Histomorphological Features of Cutaneous Adnexal Neoplasms: A Series of Eighteen Cases [PDF]

National Journal of Laboratory Medicine
Cutaneous Adnexal Neoplasms (CAN) are rare skin tumours with varied morphology that are often misdiagnosed clinically. The definitive diagnosis of these tumours can only be made by Histopathology (HP) based on their appendage differentiation. Though rare
Shaheen Khan, Shital Subhash Gosavi, Bagishri Gogate, Madhulika Hemant Katey, Alefiya Hatim Kanpurwala   +4 more
doaj   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

بررسی پتانسيل نئوپلازی خال سباسه [PDF]

, 2004
خال سباسه(Jadassohn) هامارتومی است که ترکيبی از ناهنجاری‌های اپيدرمال و غدد آپوکرين، سباسه و فوليکولار می‌باشد. به طور کلاسيک، چندين نوع نئوپلازی خوش خيم و بدخيم جلدی، با اين هامارتوما در ارتباط می‌باشند.
تکليف, ماه جبین, جليلوند, احمد   +1 more
core  

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Chondroid Syringoma and Eccrine Spiradenoma [PDF]

, 2011
Fine needle aspiration cytology (FNAC) is a well established diagnostic tool. However, most clinicians prefer to diagnose suspected skin tumors by excisional biopsy as they are easily accessible and hence benign skin adnexal tumors are rarely encountered
Fernandes, H, Jayaprakash, CS, Lyngdoh, RH, Marla, NJ, Naik, RCN, Pai, MR, Pailoor, K   +6 more
core  

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source