Results 141 to 150 of about 501,124 (211)

Inferior vena cava hyperechoic structure in a patient with cardiac myxoma: a surgical case report and literature review. [PDF]

Gen Thorac Cardiovasc Surg Cases
Yasumura H, Matsuba T, Ibi R, Minagoe S, Hiramine A, Ogata Y, Shimoishi K, Fukumoto Y, Yotsumoto G, Soga Y.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Develop a novel non-coplanar trajectory optimization algorithm for an efficient 4pi spot-scanning proton Arc (SPArc_-4pi) treatment delivery. [PDF]

Med Phys
Cong X, Chen S, Liu P, Chen P, Xu X, Li X, Chen P, Chinnaiyan P, Ding X.   +8 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Nomogram for predicting left atrial appendage dense spontaneous echo contrast and/or thrombosis (dense spontaneous echo contrast/left atrial appendage thrombus): a comparison with CHADS₂ and CHA₂DS₂-VASc scores based on three-dimensional transesophageal echocardiography. [PDF]

Quant Imaging Med Surg
Guo F, Wang X, Ye N, Liu X, Yang S, Chen K, Li J, An Y, Wang Z, Han X, Wu J, Nie F.   +11 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Differences in outcomes regarding quality and speed between male and female endoscopists in a virtual gastroscopy course. [PDF]

Front Surg
Young N, Elbe P, Höög C, Oussi N, Swahn F, Kjellman M, Sandblom G, Enochsson L.   +7 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

An Offline Digital-Twin-Assisted Decision-Support Framework for Dynamic RO Under Kuwait Solar-Availability Conditions. [PDF]

Membranes (Basel)
Alelaj FM, Bou-Rabee MA, Fadel M, Aziz S, Mir AA, Alharbi A, Al-Sairfi H.   +6 more
europepmc   +1 more source