Results 41 to 50 of about 30,661 (276)

Approximation Models of Orthodromic Navigation [PDF]

TransNav, 2011
The paper deals with two different approaches to orthodromic navigation approximation, the secant method and the tangent method. Two ways of determination of orthodromic interposition coordinates will be presented with the secant method.
Serđo Kos, David Brčic
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Associativity of the Secant Method [PDF]

The American Mathematical Monthly, 2002
This article has been published in the March 2002 issue of American Mathematical Monthly. ; Iterating a function like 1+1/x gives a sequence which converges to the Golden Mean but does so at a much slower rate than those sequences derived from Newton's method or the secant method.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Constraints on the Detectability of Cosmic Topology from Observational Uncertainties

, 2003
Recent observational results suggest that our universe is nearly flat and well modelled within a $\Lambda$CDM framework. The observed values of $\Omega_{m}$ and $\Omega_{\Lambda}$ inevitably involve uncertainties.
B Mota, Bennet C L, Blanl?il V Roukema B F, Bond J R, Bond J R, Cornish N J, Cornish N J, Ellis G F R, Ellis G F R, Evrard August E, Gausmann E, Gomero G I, Gomero G I, Gomero G I, Gomero G I, Hajian A Souradeep T, Hodgson C D, Inoue K T, Inoue K T, Lange A E, Lee A T Padmanabhan T Sethi S K, Lehoucq R, Lehoucq R, Lehoucq R, Lehoucq R, Levin J J, Levin J J, Levin J J, Levin J J, Luminet J-P Roukema B F, M J Rebouças, Muller D, Perlmutter S, R Tavakol, Rebouças M J, Riazuelo A Uzan J-P Lehoucq R Weeks J, Rocha G Cayon L Bowen R Canavezes A Silk J Banday A J Gorski K M, Roukema B F, Roukema B F, Roukema B F, Sokolov D D, Sokolov D D, Sokolov I I, Spergel D N, Starkman G D, Starobinsky A A, Uzan J-P, Uzan J-P Kirchner U Ellis G F R, Uzan J-P Riazuelo A Lehoucq R Weeks J, Weeks J R, Weeks J R, Weeks J R Lehoucq R Uzan J-P, Zeldovich Ya B   +52 more
core   +1 more source

An efficient methodology to estimate probabilistic seismic damage curves [PDF]

, 2019
The incremental dynamic analysis (IDA) is a powerful methodology that can be easily extended for calculating probabilistic seismic damage curves. These curves are metadata to assess the seismic risk of structures.
Barbat Barbat, Horia Alejandro, Hurtado Gómez, Jorge Eduardo, Pujades Beneit, Lluís, Vargas Alzate, Yeudy Felipe   +3 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Semilocal convergence conditions for the secant method, using recurrent functions

Journal of Numerical Analysis and Approximation Theory, 2011
Using our new concept of recurrent functions, we present new sufficient convergence conditions for the secant method to a locally unique solution of a nonlinear equation in a Banach space.
Ioannis K. Argyros, Saïd Hilout
doaj   +2 more sources