Results 141 to 150 of about 37,162 (308)

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Second-Generation Antipsychotics and Suicide

The Journal of Clinical Psychiatry, 2021
openaire   +3 more sources

SEMASEARCH Study Design: Real‐World Evaluation of Semaglutide 2.4 mg in Adults With Severe Obesity Underrepresented in Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Although semaglutide 2.4 mg has demonstrated significant weight loss efficacy in clinical trials, real‐world data, particularly with regard to clinically complex and underrepresented populations, remain limited. Objectives The study aims to assess the real‐world effectiveness and patient‐reported outcomes associated with the use of ...
Pierre Bel Lassen, David Jacobi, Marie‐Claude Brindisi, Jean‐Baptiste Bonnet, Fabien Subtil, Sylvie Bin, Fanny Abad, Christine Poitou, Bérénice Segrestin, Séverine Ledoux, Bénédicte Gaborit, Judith Aron‐Wisnewsky, Claire Carette, Mohamed Zerguine, Blandine Gatta‐Cherifi, Didier Quilliot, Emilie Montastier, Antoine Avignon, Héléna Mosbah, Sébastien Czernichow, Emmanuel Disse   +20 more
wiley   +1 more source

Parkinson's Disease and Salivary Issues: A Survey

Gerodontology, EarlyView.
ABSTRACT Background Salivary dysfunction, including xerostomia and drooling, is common in Parkinson's disease and further impairs oral health and quality of life, which are already compromised in this population. Their effective management demands deeper insight into the complexity of salivary dysfunction.
Beau D. M. van Dijk, Merel C. Verhoeff, Niels van der Aa, Frank Lobbezoo   +3 more
wiley   +1 more source

Prescribing patterns of low doses of antipsychotic medications in older Asian patients with schizophrenia, 2001-2009 [PDF]

, 2017
Background: This study examined the use of low doses of antipsychotic medications (300mg/day CPZeq or less) in older Asian patients with schizophrenia and its demographic and clinical correlates.
Chee, Kok-Yoon, Chiu, Helen F. K., Chong, Mian-Yoon, Chung, Eun-Kee, Dickerson, Faith, Fujii, Senta, He, Yan-Ling, Kreyenbuhl, Julie, Kua, Ee-Heok, Lai, Kelly Y. C., Lee, Edwin H. M., Sartorius, Norman, Shinfuku, Naotaka, Si, Tian-Mei, Sim, Kang, Tan, Chay-Hoon, Trivedi, Jitendra K., Udomratn, Pichet, Ungvari, Gabor S., Wang, Chuan-Yue, Xiang, Yu-Tao, Yang, Shu-Yu, Yong, Michael K. H.   +22 more
core  

Holistic approach to substance‐induced psychosis

Addiction, EarlyView.
Julia M. Lappin, Shane Darke, Michael Farrell   +2 more
wiley   +1 more source

Medical Knowledge Integration Into Reinforcement Learning Algorithms for Dynamic Treatment Regimes

International Statistical Review, EarlyView.
Summary The goal of precision medicine is to provide individualised treatment at each stage of chronic diseases, a concept formalised by dynamic treatment regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from clinical data to enhance therapeutic effectiveness.
Sophia Yazzourh, Nicolas Savy, Philippe Saint‐Pierre, Michael R. Kosorok   +3 more
wiley   +1 more source

Intervention and Strategies to Prevent Workplace Violence From Patients and Visitors Against Nurses: An Integrative Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise the existing literature on effective interventions aligned with the 2015 U.S. Occupational Safety and Health Administration guidelines to address workplace violence against nurses. Design An integrative review. Methods PubMed, Embase, CINAH, and PsycINFO databases were searched for articles published between 2010 and 2023 ...
Islam Qasem, Gordon L. Gillespie
wiley   +1 more source

Exploring the Presence and Impact of Advanced Nursing Roles in Care Homes and Charitable Organisations: An International Systematic Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Introduction Investing in advanced nursing roles (AN) in social care is a strategic priority to address workforce challenges, create new career pathways, improve outcomes and future‐proof the sector. However, there is limited understanding of these roles globally.
Siobhán Kelly, Claire Pryor, Melanie Stephens, Vanessa Heaslip   +3 more
wiley   +1 more source

From the ICU Bedside: Applying the Transnational Clinical Academic Doctorate Lens to a Clinically Embedded PhD Journey

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To critically reflect on a transnational, clinically embedded doctoral journey undertaken during and after the COVID‐19 pandemic, and to draw conceptual and systemic lessons for doctoral education and clinical academic nursing pathways. Background Reflective accounts of doctoral study exist, yet few examine practice‐based PhDs conducted ...
Gideon U. Johnson
wiley   +1 more source