Results 231 to 240 of about 300,028 (288)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Over 1.65 GW cm^-2 sr^-1 brightness 590 nm yellow second-harmonic generation in MOCVD-grown high-strain InGaAs/GaAs quantum well VECSEL. [PDF]

Light Sci Appl
Zhang Z, Zhan W, Xiao Y, Luo C, Zhou H, Yang W, Cheng Y, Yu H, Li Q, Li X, Zhang C, Wang J.   +11 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Second-harmonic generation microscopy of murine scleral remodeling by collagenase and reparative collagen mimetic peptides. [PDF]

Front Med (Lausanne)
Savage DE, Tecse A, Zhou J, Germann JA, Buckley MR, Baratta RO, Del Buono BJ, Schlumpf E, Telias M, Marcos S.   +9 more
europepmc   +1 more source

3D Large‐Scale Subwavelength‐Resolution Sound Sheet Tomography Based on an Active and Programmable Circular Meta‐Array

Advanced Science, EarlyView.
A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang, Zi‐Bin Lin, Zhuo Chen, Zhao‐Hui Liu, Jin‐Lian He, Jun‐Jie Song, Long‐Sheng Zeng, Liang Zhou, Ming‐Yue Ding, Yu‐Gui Peng, Ming Yuchi, Xue‐Feng Zhu   +11 more
wiley   +1 more source

Nanoscale Control of Aggregation-Induced Emission and Second Harmonic Generation in a Dicyano Distyrylbenzene-Appended Polymer Using Optical Trapping. [PDF]

J Phys Chem B
Wang SF, Tseng KC, Nakabayashi M, Hayashi S, Ishiwari F, Sugiyama T.   +5 more
europepmc   +1 more source

Exceptional Second Harmonic Generation in Ultraviolet Nonlinear Optical Oxyfluoroniobate Crystals via Structural Fingerprint Optimization of Polar Chains. [PDF]

Angew Chem Int Ed Engl
Jin C, Li Y, Kim JS, Lim JH, Huang H, Chen CA, Lee J, Heo Y, Zhang B, Jang JI, Ok KM.   +10 more
europepmc   +1 more source

Interface second harmonic generation enhancement in bulk WS₂/MoS₂ hetero-bilayer van der Waals nanoantennas. [PDF]

Light Sci Appl
Tognazzi A, Franceschini P, Biechteler J, Baù E, Cino AC, Tittl A, De Angelis C, Sortino L.   +7 more
europepmc   +1 more source

Evaluation of the effects of clearing agents, fixation, and process durations on cardiovascular tissue imaging with second harmonic generation and multi-photon modalities. [PDF]

Front Bioeng Biotechnol
Makki M, Molander ZA, Pineda-Castillo SA, Laurence DW, Singhal S, Eltwafsha Y, Holzapfel GA, Gu T, Lee CH.   +8 more
europepmc   +1 more source