Results 31 to 40 of about 1,211,669 (319)

Corrective Feedback in Second Language Acquisition

open access: yesStudies in Applied Linguistics & TESOL, 2002
Over the last few years, the role played by corrective feedback in language acquisition has become a highly controversial issue. In the field of First Language Acquisition (FLA), researchers express strong reservations concerning the effect that negative
Mounira El Tatawy
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Fossilization in Adult Second Language Acquisition

open access: yesStudies in Applied Linguistics & TESOL, 2005
Most non-native speakers would agree that it is sometimes frustrating to communicate in another language. Many have embarrassing stories about how they have been misunderstood or have not been able to convey their intended messages at all.
Özlem Pazvant
doaj   +1 more source

Response through the Intentional Arc: Merleau-Ponty, Dreyfus and Second Language Acquisition [PDF]

open access: yes, 2019
Language, when considered as part of the lived experience of human beings, fails to be reduced to mere representation. In line with non-representationalist understandings of the mind and knowledge-how centered understandings of knowledge, purposiveness ...
Burnett, Mia
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Learner internal psychological factors [PDF]

open access: yes, 2012
Book synopsis: What is language and how can we investigate its acquisition by children or adults? What perspectives exist from which to view acquisition? What internal constraints and external factors shape acquisition?
Dewaele, Jean-Marc
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Late L2 Acquisition and Phonological Memory Development [PDF]

open access: yes, 2017
The development of phonological memory, a subdivision of short term memory, is crucial to learning and analyzing sequences of sounds to form words and phrases.
Westerhoff, Madeline
core   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

open access: yesFEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

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