Results 21 to 30 of about 13,108,497 (315)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structure Theory for Second Order 2D Superintegrable Systems with 1-Parameter Potentials

open access: yes, 2009
The structure theory for the quadratic algebra generated by first and second order constants of the motion for 2D second order superintegrable systems with nondegenerate (3-parameter) and or 2-parameter potentials is well understood, but the results for ...
Willard Miller Jr.   +7 more
core   +1 more source

Stochastic programming with multivariate second order stochastic dominance constraints with applications in portfolio optimization [PDF]

open access: yes, 2014
In this paper we study optimization problems with multivariate stochastic dominance constraints where the underlying functions are not necessarily linear. These problems are important in multicriterion decision making, since each component of vectors can
Xu, Huifu   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A second order cell method for Poisson's equation

open access: yes, 2010
The Cell Method, similar to the Finite Integration Technique, is a well-established numerical method for the solution of field problems, however an often raised criticism is that it is limited to constant fields within elements.
Alotto, P.   +7 more
core   +1 more source

Second-Order Reversed Phi [PDF]

open access: yesPerception & Psychophysics, 1999
Abstract A second-order reversed-phi stimulus is composed of moving features (areas filled with texture) whose overall amount of texture-contrast is reversed between successive frames. In peripheral vision, the stimulus is perceived as moving in the reversed direction (opposite to the feature displacement).
Z L, Lu, G, Sperling
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

New Horizons for Second-Order Cybernetics [PDF]

open access: yes, 2016
Open peer commentary on the article “Design Research as a Variety of Second-Order Cybernetic Practice” by Ben Sweeting. Upshot: This commentary supports Sweeting’s case for the relationship between the design tradition, second-order cybernetics and ...
Alexander Riegler   +4 more
core   +1 more source

Home - About - Disclaimer - Privacy