Results 41 to 50 of about 17,700,714 (250)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Metacommunication as Second Order Communication

open access: yesKOME: An International Journal of Pure Communication Inquiry, 2017
By giving full emphasis to the impossibility of not to communicate, the first axiom of communication stresses how communication is an event not subject to cessation.
Samuel Mateus
doaj   +1 more source

Numerical Analysis of Convection–Diffusion Using a Modified Upwind Approach in the Finite Volume Method

open access: yesMathematics, 2020
The main focus of this study was to develop a numerical scheme with new expressions for interface flux approximations based on the upwind approach in the finite volume method.
Arafat Hussain   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Second-Order Damped Differential Equations with Superlinear Neutral Term: New Criteria for Oscillation

open access: yesAxioms
This paper focuses on establishing new criteria to guarantee the oscillation of solutions for second-order differential equations with a superlinear and a damping term.
Asma Al-Jaser   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Oscillation criteria for second-order nonlinear delay dynamic equations of neutral type

open access: yesAdvances in Difference Equations, 2018
We investigate oscillatory behavior of solutions to a class of second-order nonlinear neutral delay dynamic equations with nonpositive neutral coefficients. In particular, we study the corresponding noncanonical neutral differential equations.
Ming Zhang   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

SECOND ORDER OPTIMALITY CONDITIONS

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
Nonlinear programming problems are studied. Necessary second order optimality conditions are proved under minimal assumptions about constraints.
A. E. Leschov, L. I. Minchenko
doaj  

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