Results 61 to 70 of about 3,314,194 (266)
Second order tangency conditions and differential inclusions: a counterexample and a remedy
Electronic Journal of Differential Equations, 2009 In this paper we show that second order tangency conditions are superfluous not to say useless while discussing the existence condition for certain second order differential inclusions. In this regard, a counterexample is provided even in the simpler
Corneliu Ursescu
doaj
On the Undecidability of Second-Order Unification
Information and Computation, 2000 This work was partially supported by Project MODELOGOS (TIC97-0579-C02-01) funded by the CICYT, and the ESPRIT Basic Research Action CCL. This paper is based on preliminary results in (Levy, 1998; Veanes, 1998; Levy and Veanes, 1998). The second author worked at Max-Planck-Institute of Computer Science, Saarbruecken, Germany, when this paper was ...
Jordi Levy, Margus Veanes
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Multivalued second order differential problem
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2012 Let $K$ be a closed convex cone with nonempty interior in a real Banach space and let $F,G,Hcolon K o cc(K)$ be three given continuous additive set-valued functions.
Ewelina Mainka-Niemczyk
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Notre Dame Journal of Formal Logic, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hazen, Allen P. +1 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source