Results 101 to 110 of about 2,522,578 (311)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the dynamics of second-order Lagrangian systems

Electronic Journal of Differential Equations, 2017
In this article we are concerned with improving the twist condition for second-order Lagrangian systems. We characterize a local Twist property and demonstrate how results on the existence of simple closed characteristics can be extended in the case ...
Ronald Adams, William D. Kalies, Robert C. A. M. Vandervorst   +2 more
doaj  

Fast Second Order Original Prony’s Method for Embedded Measuring Systems

Metrology and Measurement Systems, 2017
The paper presents a method of adaptation of the original second order Prony’s method for applications in lowcost digital measurement systems with low computing performance.
Zygarlicki Jarosław
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Optimal Active Disturbance Rejection Control for Second Order Systems

IEEE Access
This study addresses the control of second-order dynamic systems in the presence of uncertainties and disturbances using an optimized Active Disturbance Rejection Control (ADRC) approach.
J. J. Carreno-Zagarra, J. C. Moreno, J. L. Guzman   +2 more
doaj   +1 more source

Pseudo-second order model for sorption processes

, 2009
[[abstract]]A literature review of the use of sorbents and biosorbents to treat polluted aqueous effluents containing dyes:organics or metal ions has been conducted.
Ho, Y.S.;McKay, G.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Homoclinics for strongly indefinite almost periodic second order Hamiltonian systems

Advances in Nonlinear Analysis, 2017
Under certain assumptions, we prove the existence of homoclinic solutions for almost periodic second order Hamiltonian systems in the strongly indefinite case.
Pankov Alexander
doaj   +1 more source

Some results on design of second-order sliding mode controller for nonlinear systems

, 2015
In this paper the problem of designing a second-order sliding mode controller for nonlinear systems with bounded uncertainties is addressed. The adding a power integrator technique is applied to develop a new second-order sliding mode control algorithm ...
Ding, Shihong, Wei Xing Zheng, Shihong Ding, Zheng, Wei Xing (R8901)   +3 more
core   +1 more source