Results 21 to 30 of about 260,772 (213)

The theory and phenomenology of constitutional dismemberment

open access: yesRevista de Investigações Constitucionais, 2020
One of the most spectacle features anchored in Richard Albert’s Constitutional Amendments: Making, Breaking, and Changing Constitutions is the theory of constitutional dismemberment.
Yota Negishi
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The Authority of Reflection

open access: yesTheoria, 2009
Richard Moran defends the irreducible authority of the first-person in a deliberative perspective. This article argues that authority of self-reflection is best understood as a relation of mutual recognition between self and others, hence from a second ...
Carla Bagnoli
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

A Room Monitoring System Using Deep Learning and Perspective Correction Techniques

open access: yesApplied Sciences, 2020
Studies on room monitoring have only focused on objects in a singular and uniform posture or low-density groups. Considering the wide use of convolutional neural networks for object detection, especially person detection, we use deep learning and ...
Huu-Huy Ngo   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Pielęgnowanie intymności – użycie drugiej osoby gramatycznej w poezji lirycznej

open access: yesTeksty Drugie, 2020
Philosophers discussing lyric poetry often focus on first personal expression as a mark of the “lyric” which has resulted in a narrow characterisation of the nature of intimacy in lyric poetry that focuses on the individual poet, poetic voice, or reader.
Karen Simecek
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

More Than One Encounter: Exploring the Second-Person Perspective and the In-Between

open access: yesOpen Philosophy
In this essay, I explore the notion of the encounter as a challenge to the second-person perspective. I do so by turning to Jacques Derrida’s account of the encounter with the associated notions of address, second-person perspective, otherness, and the ...
Hansen Bjarke Mørkøre Stigel
doaj   +1 more source

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