Results 101 to 110 of about 1,276,307 (288)

One-Step Family of Three Optimized Second-Derivative Hybrid Block Methods for Solving First-Order Stiff Problems

Journal of Applied Mathematics
This paper introduces a novel approach for solving first-order stiff initial value problems through the development of a one-step family of three optimized second-derivative hybrid block methods.
Saidu Daudu Yakubu, Precious Sibanda
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Detection of SPAD Content in Leaves of Grey Jujube Based on Near Infrared Spectroscopy

Horticulturae
The efficient and non-destructive inspection of the chlorophyll content of grey jujube leaf is of great significance for its growth surveillance and nutritional diagnosis. Near-infrared spectroscopy combined with chemometric methods provides an effective
Lanfei Wang, Junkai Zeng, Mingyang Yu, Weifan Fan, Jianping Bao   +4 more
doaj   +1 more source

The Neumann Problem for Hessian Equations

, 2015
In this paper, we prove the existence of a classical solution to a Neumann boundary problem for Hessian equations in uniformly convex domain. The methods depend upon the established of a priori derivative estimates up to second order.
Ma, Xinan, Qiu, Guohuan
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Simple Spectrophotometric Methods for Determination of Tenofovir Fumarate and Emtricitabine in Bulk Powder and in Tablets

Journal of Spectroscopy, 2013
Two simple and selective methods were developed for the simultaneous determination of tenofovir fumarate (TEN) and emtricitabine (EMT) in combined tablets.
Mohammad H. AbdelHay, Azza A. Gazy, Rasha A. Shaalan, Heba K. Ashour   +3 more
doaj   +1 more source

Second Derivative Mono-Implicit Runge-Kutta Methods

Earthline Journal of Mathematical Sciences
Mono-implicit Runge-Kutta (MIRK) methods are Runge-Kutta methods having its stages depending on its output. In this paper, we develop a family of second derivative mono-implicit Runge-Kutta (SDMIRK) methods for the numerical solution of stiff initial value problems (IVPs) in ordinary differential equations (ODEs).
A. G. Ariwayo, P. O. Olatunji, R. I. Okuonghae   +2 more
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

A Class of Two-Derivative Two-Step Runge-Kutta Methods for Non-Stiff ODEs

Journal of Applied Mathematics, 2019
In this paper, a new class of two-derivative two-step Runge-Kutta (TDTSRK) methods for the numerical solution of non-stiff initial value problems (IVPs) in ordinary differential equation (ODEs) is considered.
I. B. Aiguobasimwin, R. I. Okuonghae
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source