Results 71 to 80 of about 1,276,307 (288)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A New Family of Iterative Methods Based on an Exponential Model for Solving Nonlinear Equations
Journal of Applied Mathematics, 2013 We present two new families of iterative methods for obtaining simple roots of nonlinear equations. The first family is developed by fitting the model m(x)=epx(Ax2+Bx+C) to the function f(x) and its derivative f′(x), f″(x) at a point xn.
Tianbao Liu, Hengyan Li, Zaixiang Pang
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Electronic Journal of Differential Equations, 2014 In this article, we study the existence of solutions for nonlinear impulsive problems. We show the existence of classical solutions by using variational methods.
Jian Liu, Zengqin Zhao
doaj
Numerical Methods and Analysis via Random Field Based Malliavin Calculus for Backward Stochastic PDEs [PDF]
, 2013 We study the adapted solution, numerical methods, and related convergence analysis for a unified backward stochastic partial differential equation (B-SPDE).
Dai, Wanyang
core
Accurate gradient computations at interfaces using finite element methods
, 2017 New finite element methods are proposed for elliptic interface problems in one and two dimensions. The main motivation is not only to get an accurate solution but also an accurate first order derivative at the interface (from each side). The key in 1D is
Li, Zhilin +3 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Classifying Galileon $p$-form theories
, 2017 We provide a complete classification of all abelian gauge invariant $p$-form theories with equations of motion depending only on the second derivative of the field---the $p$-form analogues of the Galileon scalar field theory.
Deffayet, Cédric +3 more
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Second order adjoints for solving PDE-constrained optimization problems [PDF]
, 2010 Inverse problems are of utmost importance in many fields of science and engineering. In the variational approach inverse problems are formulated as PDE-constrained optimization problems, where the optimal estimate of the uncertain parameters is the ...
Alexe, Mihai +2 more
core +1 more source