DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. [PDF]
, 2014 Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). While its physiological function(s) are not completely clear, DJ-1 protects neurons against oxidative stress in both in vitro and in vivo ...
Aleyasin, Hossein +15 more
core +5 more sources
Implementation of the IMO Second Generation Intact Stability Guidelines
Journal of Marine Science and Engineering, 2021 This paper provides a discussion of the technical and theoretical ambiguities, requirements, and limitations to develop a practical implementation of the IMO Second Generation Intact Stability criteria.
Kyle E. Marlantes +2 more
doaj +1 more source
Primary stability of cementless threaded acetabular cups at first implantation and in the case of revision regarding micromotions as indicators [PDF]
, 2012 The primary stability of cementless total hip endoprosthesis is of vital importance for proximate, long-term osteointegration. The extent of micromotions between implant and acetabulum is an indicator of primary stability.
Buerkner, Andreas +6 more
core +1 more source
Parametric design and holistic optimisation of post-panamax containerships [PDF]
, 2018 The fluctuation of fuel price levels, along with the continuous endeavour of the shipping industry for economic growth and profits has led the shipbuilding industry to explore new designs for various types of merchant ships. Moreover, the introduction of
Boulougouris, Evangelos +2 more
core +2 more sources
Excessive acceleration simplified Operational Guidance
International Journal of Naval Architecture and Ocean Engineering, 2022 Excessive acceleration criterion, developed by the International Maritime Organization within the Second Generation Intact Stability Criteria, deals with lateral accelerations experienced by people onboard.
Ermina Begović +3 more
doaj +1 more source
Dynamic stability vulnerability assessment and optimization of large ocean-going passenger vessel
Zhongguo Jianchuan Yanjiu, 2021 ObjectivesThe dynamic stability of large ocean-going passenger vessel is of great important to ensuring the safety of a large number of passengers. Thus, it is necessary to carry out vulnerability assessment and optimization for typical failure modes ...
Xiaoqing QIN +3 more
doaj +1 more source
Multiple types of control by identified interneurons in a sensory-activated rhythmic motor pattern. [PDF]
, 2001 Modulatory interneurons that can drive central pattern generators (CPGs) are considered as good candidates for decision-making roles in rhythmic behaviors.
Benjamin, Paul R +2 more
core +2 more sources
Analysis of Satellite AIS Data to Derive Weather Judging Criteria for Voyage Route Selection [PDF]
TransNav, 2017 The operational limitations are discussed at the IMO as a part of the second generation intact stability criteria. Since it is a first attempt to introduce operational efforts into safety regulations, comprehensive discussions are necessary to realize ...
Michio Fujii +2 more
doaj +1 more source
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]
, 2014 Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline +5 more
core +3 more sources
한국해양공학회지, 2020 A review of the 2nd generation of intact stability by the International Maritime Organization is performed. The main issues with the new stability criteria are reviewed.
Jaeho Chung +3 more
doaj +1 more source