An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Efficiency and prices in economies of overlapping generations [PDF]
In a general economy of overlapping generations, I introduce a notion of uniform ine±ciency, corresponding to the occurrence of a Pareto improvement with a small uniform destruction of resources (Debreu [11]).
Gaetano Bloise
core
Giant enhancement of optical nonlinearity from monolayer MoS2 using plasmonic nanocavity
NanophotonicsThe particle-on-mirror nanocavity, supporting multiple plasmonic resonances, provides an ideal platform to efficiently boost the nonlinear optical processes at the nanoscale.
Hou Liping +5 more
doaj +1 more source
Effects of Different Selection Methods Using Body Weight on Egg Yield Parameters in Japanese Quail
Brazilian Journal of Poultry ScienceThis experiment was conducted to investigate the effects of different selection methods of parent lines on the body weight of Japanese quails. For this purpose, line M55 was subjected to individual selection for body weight at 5 weeks of age, while a ...
M Baylan
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The contextual database of the Generations and Gender Program: overview, conceptual framework and the link to the Generations and Gender Survey [PDF]
This paper follows two aims. First it intends to give an overview of the contextual database of the Generations and Gender Program and how it is linked to the Generations and Gender Survey.
Martin Spielauer
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Stackelberg Differential Game with Overlapping Generations [PDF]
We study a differential game, for the extraction of a renewable resource, in which players are overlapping generations of extractors. The framework of overlapping generation allows us to consider both intragenerational (players in the same generation ...
Luca Grilli
core
I giovani migranti nelle scuole italiane: percorsi formativi, disuguaglianze, risorse
REMHU: Revista Interdisciplinar da Mobilidade HumanaNel 2013 la presenza di minori stranieri in Italia ha raggiunto quote numeriche importanti, soprattutto per la presenza di seconde generazioni (44%).
Maddalena Colombo
doaj