Results 161 to 170 of about 3,975,563 (312)

Oscillation criteria for forced second-order mixed type quasilinear delay differential equations

open access: yesElectronic Journal of Differential Equations, 2010
This article presents new oscillation criteria for the second-order delay differential equation $$ (p(t) (x'(t))^{alpha})' + q(t) x^{alpha}(t - au) + sum_{i = 1}^{n} q_{i}(t) x^{alpha_{i}}(t - au) = e(t) $$ where $au geq 0$, $p(t) in C^1[0, infty)$,
Sowdaiyan Murugadass   +2 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Second-order approximation for adaptive regression estimators. [PDF]

open access: yes
We derive asymptotic expansions for semiparametric adaptive regression estimators. In particular, we derive the asymptotic distribution of the second-order effect of an adaptive estimator in a linear regression whose error density is of unknown ...
Linton, Oliver, Xiao, Zhijie
core   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Annulus oscillation criteria for second order nonlinear elliptic differential equations with damping

open access: yesElectronic Journal of Differential Equations, 2009
We establish oscillation criteria for the second-order elliptic differential equation $$ ablacdot(A(x) abla y)+B^T(x) abla y+q(x)f(y)=e(x), quad xinOmega, $$ where $Omega $ is an exterior domain in $mathbb{R}^N$.
Rong-Kun Zhuang
doaj  

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Interval criteria for oscillation of second-order impulsive differential equation with mixed nonlinearities

open access: yesElectronic Journal of Differential Equations, 2011
We establish sufficient conditions for the oscillation of all solutions to the second-order impulsive differential equation $$displaylines{ ig(r(t)x'(t)ig)'+p(t)x'(t)+q(t)x(t)+sum_{i=1}^n q_i(t)|x(t)|^{alpha_i}hbox{sgn} x(t)=e(t),quad teq au_k,cr x({
Velu Muthulakshmi, Ethiraju Thandapani
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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