Results 141 to 150 of about 3,975,563 (312)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Preference and Order in First and Second Language Referential Strategies [PDF]
, 1991 Kellerman, Ammerlaan, Bongaerts, and Poulisse (1986) examined referential strategies used by Dutch speakers of English as a second language in a shapedescription task. Kellerman, et al.
Russell, George
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Chinese speakers' acquisition of English conditionals: Acquisition order and L1 transfer effects [PDF]
, 2000 This study examines how the syntactic complexity of English conditionals and first language transfer influence Chinese ESL learners’ acquisition order of conditionals.
Chou, Chen-Ling
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Efficient Hyperkernel Learning Using [PDF]
, 2008 —The kernel function plays a central role in kernel methods. Most existing methods can only adapt the kernel parameters or the kernel matrix based on empirical data. Recently, Ong et al.
Second-order Cone Programming
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Publicacions Matemàtiques, 1992 The author introduces the notion of a \(G_ 1\)-structure of order 2 (briefly \(G^ 2_ 1\)- structures.) Let us recall that a \(G_ 1\)- structure on a manifold \(V\) is defined by an endomorphism \(J\) of the tangent bundle \(TV\) with constant rank and such that \(J^ 2 = 0\). Then a \(G^ 2_ 1\)-structure is a generalization of almost tangent structures.
openaire +6 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source