Results 41 to 50 of about 16,247,611 (228)

Dirichlet problem for second-order abstract differential equations

Electronic Journal of Differential Equations, 2020
We study the well-posedness in the space of continuous functions of the Dirichlet boundary value problem for a homogeneous linear second-order differential equation u''+Au = 0, where A is a linear closed densely defined operator in a Banach space. We
Giovanni Dore
doaj  

Boundary value problems for second-order causal differential equations

Boundary Value Problems, 2022
This paper focuses on second-order differential equations involving causal operators with nonlinear two-point boundary conditions. By applying the monotone iterative technique in the presence of upper and lower solutions, with a new comparison theorem ...
Wenli Wang, Peiguang Wang
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Second-Order L1 Schemes for Fractional Differential Equations

Fractal and Fractional
Difference schemes for the numerical solution of fractional differential equations rely on discretizations of the fractional derivative. In this paper, we obtain the second-order expansion formula for the L1 approximation of the Caputo fractional ...
Yuri Dimitrov, Slavi Georgiev, Radan Miryanov, Venelin Todorov   +3 more
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adomian Decomposition Method to Solve the Second Order Ordinary Differential Equations with Constant Coefficient

, 2023
: In this paper, we will display Adomian decomposition method for solving second-order ordinary differential equations with constant coefficient. The Adomian decomposition method(ADM) is a creative and effective method for exact solution. It is important
Mohammed Ali Qasem Mohsen, Yahya Qaid Hasan   +1 more
core   +1 more source

Strong oscillations for second order nonlinear functional differential equations

International Journal of Mathematics and Mathematical Sciences, 1990
In this paper, we establish some strongly oscillation theorems for nonlinear second order functional differential equationx″(t)+p(t)f(x(t),x(g(t)))=0without assuming that g(t) is retarded or advanced.
Jurang Yan
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Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Solve the Second Order Ordinary Differential Equations by Adomian Decomposition Method

, 2023
: The Adomian decomposition model (ADM) is described by Evans and Raslan (2005) as a semi-analytical model used to solve partial and ordinary non-linear differentials.
Yousef Ali Sulaiman Alsulaiman, Ahmad M. D. Al-Eybani   +1 more
core   +1 more source

Homoclinic Solutions of Singular Nonautonomous Second-Order Differential Equations

Boundary Value Problems, 2009
This paper investigates the singular differential equation , having a singularity at . The existence of a strictly increasing solution (a homoclinic solution) satisfying , is proved provided that has two zeros and a linear behaviour near .
Rachůnková Irena, Tomeček Jan   +1 more
doaj   +2 more sources