Results 61 to 70 of about 2,160 (178)

Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa‐Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers

Movement Disorders, EarlyView.
ABSTRACT Background Dopa‐responsive dystonia is caused by pathogenic variants in the GCH1 gene. Although its clinical features and reduced penetrance are known, in vivo metabolic and structural alterations in symptomatic (sMC) and asymptomatic mutation carriers (aMC) remain poorly understood.
Jannik Prasuhn, Leon van Well, Marta M. Pokotylo, Feline Hamami, Joke‐Lina Aßmann, Katja Lohmann, Maximilian G. Ködderitzsch‐Mertins, Julia Henkel, Jan Uter, Alexander Münchau, Christine Klein, Anne Weissbach, Norbert Brüggemann   +12 more
wiley   +1 more source

Omics Insights Into the Effects of Highbush Blueberry and Cranberry Crop Agroecosystems on Honey Bee Health and Physiology

PROTEOMICS, EarlyView.
ABSTRACT Honey bees (Apis mellifera) are vital pollinators in fruit‐producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes.
Huan Zhong, Yuming Shi, Aleksandra Kozlova, Renata Moravcova, Jason C. Rogalski, Aidan Jamieson, Lance Lansing, Kyung‐Mee Moon, Xiaojing Yuan, Amanda S. Gregoris, Heather Higo, Julia Common, Ida M. Conflitti, Mateus Pepinelli, Lan Tran, Morgan Cunningham, Hosna Jabbari, Syed Abbas Bukhari, Sarah K. French, Rodrigo Ortega Polo, Shelley E. Hoover, Stephen F. Pernal, Pierre Giovenazzo, M. Marta Guarna, Amro Zayed, Leonard J. Foster   +25 more
wiley   +1 more source

Hybrid physics–data‐driven modeling for sea ice thermodynamics and transfer learning

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Icepack–NN, a machine‐learning‐based hybrid version of the sea‐ice column model Icepack, is developed to correct state‐dependent forecast errors arising from misspecified snow thermodynamics, using neural networks applied online within the physical model.
G. De Cillis, A. Carrassi, J. Brajard, L. Bertino, M. Broccoli, D. Iovino, T.S. Finn, M. Bocquet   +7 more
wiley   +1 more source

Detecting Plateau Zokor (Eospalax baileyi) Mounds in UAV Imagery of Alpine Meadows Using Deep Learning Algorithms

Remote Sensing in Ecology and Conservation, EarlyView.
We developed PZM‐YOLO to automatically detect plateau zokor mounds in UAV imagery of alpine meadows. The model achieved reliable detection of small and densely distributed mounds under complex backgrounds, outperforming the baseline YOLOv5s. This framework supports mound counting, mound position, rodent impact assessment, and grassland restoration ...
Yang Yang, Limin Hua, Lianguo Wang, Jiazhen Li, Rui Dong, Siwei Yang   +5 more
wiley   +1 more source

Key Technical Fields and Future Outlooks of Space Manipulators: A Survey

SmartBot, EarlyView.
This paper systematically reviews the technological development of space manipulators, emphasizing the unique challenges posed by space environments. It examines four areas: structural design, modeling, planning, and control, while introducing typical ground test platforms.
Gang Chen, Zeyuan Huang, Ying Yan, Xiaokang An, Zhikai Zhao, Jirong Lin, Xiangrong Zhao, Xianyuan Gao, Junyi Zong, Xuewen Jia, Zhipeng Yao, Jianliang Liao, Ning Ji   +12 more
wiley   +1 more source

Development and Validation of a Next‐Generation Mechanistic Model of the Electric Arc Furnace

steel research international, EarlyView.
This study presents a next‐generation mechanistic model of the electric arc furnace (EAF). It describes equations for all crucial processes appearing during the steel‐recycling process in an EAF, i.e., thermal, mass, and chemical. The model was parameterized and validated using industrial EAF data.
Vito Logar, Igor Škrjanc
wiley   +1 more source

FMTNet: A Fourier‐Mamba–Transformer Enhanced Network for Medical Image Segmentation

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Models based on U‐shaped networks have achieved widespread success in the field of medical image segmentation, but their performance is generally limited by structural bottlenecks in the network. At this stage, feature maps experience a sharp decline in spatial resolution due to continuous downsampling, resulting in significant loss of ...
Shaoqiang Wang, Guiling Shi, Yuanyuan Zhang, Sibo Qiao, Yuchen Wang, Yifan Wang, Yawu Zhao, Xiaochun Cheng   +7 more
wiley   +1 more source

Drugst.One DREAM—Drug repurposing through expert annotation and modification

British Journal of Pharmacology, EarlyView.
Background and Purpose Complex diseases often lack an actionable understanding of their underlying causal biological mechanisms, which leads to treating symptoms rather than causes. Network and systems medicine define disease mechanisms through disease‐associated genes, their encoded proteins and their protein–protein interactions (PPIs), thus forming ...
Lisa M. Spindler, Johannes Kersting, Quirin Manz, Michael Hartung, Andreas Maier, Zeinab M. Mamdouh, Ana I. Casas, Jan Baumbach, Markus List   +8 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

BIOMERO 2.0: End‐to‐end FAIR infrastructure for bioimaging data import, analysis, and provenance

Journal of Microscopy, EarlyView.
Abstract We present BIOMERO 2.0, a major evolution of the BIOMERO framework that transforms OMERO into a FAIR‐compliant (findable, accessible, interoperable, and reusable), provenance‐aware bioimaging platform. BIOMERO 2.0 integrates data import, preprocessing, analysis, and workflow monitoring through an OMERO.web plugin and containerised components ...
Torec T. Luik, Joost de Folter, Rodrigo Rosas‐Bertolini, Eric A. J. Reits, Ron A. Hoebe, Przemek M. Krawczyk   +5 more
wiley   +1 more source