Results 91 to 100 of about 7,145,914 (315)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluación y diagnóstico de la Hipertensión Arterial Assessment and diagnosis of high blood pressure

Revista Cubana de Investigaciones Biomédicas, 2009
La hipertensión arterial es un factor de riesgo cuyo diagnóstico se establece por una simple variable numérica aunque se ha comprobado que es un síndrome multifactorial que produce alteraciones sistémicas, complicaciones y muerte.
Joaquín Sellén Crombet, Elizabeth Sellén Sanchén, Lourdes Barroso Pacheco, Sybert Sellén Sánchez   +3 more
doaj  

Predictive value of early MoCA score combined with serum S100 protein and 25⁃hydroxyvitamin D3 levels on secondary cognitive dysfunction in patients with cerebral infarction

Zhongguo linchuang yanjiu
Objective To explore the early Montreal Cognitive Assessment（MoCA）score and serum levels of S100 protein and 25 ⁃ hydroxyvitamin D3［25（OH）D3］in patients with cerebral infarction who had secondary cognitive dysfunction，and to analyze the predictive value ...
CHEN Yan，LIU Hui，YAN Manyun，ZHUO Ziliang，ZHAO Zongbo
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Secondary Immunodeficiency

Allergy, Asthma & Clinical Immunology
Abstract The field of medicine is constantly changing and, as healthcare providers, we are fortunate to be practicing in a time when patients are living longer and novel therapeutic options continue to evolve. However, these new advances may be associated with adverse effects that practitioners need to be aware of.
Persia Pourshahnazari, Stephen D. Betschel, Vy. H. D. Kim, Susan Waserman, Rongbo Zhu, Harold Kim   +5 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Effective pre-school, primary and secondary education project (EPPSE 3-14) : influences on students' dispositions in key stage 3 : exploring enjoyment of school, popularity, anxiety, citizenship values and academic self-concepts in year 9 [PDF]

, 2011
The Effective Pre-school, Primary and Secondary Education Project (EPPSE) has investigated the academic and social-behavioural development of approximately 3,000 children from the age of 3+ years since 1997.
Smees, R., Draghici, D., Smees, R, Siraj-Blatchford, Iram, Toth, Katalin, Taggart, Brenda, Taggart, B., Sylva, K., Melhuish, E, Sammons, Pam, Sammons, P., Siraj-Blatchford, I, Sammons, Pamela, Draghici, Diana, Sammons, P, Draghici, D, Smees, Rebecca, Sylva, K, Sylva, Kathy, Toth, K, Toth, K., Siraj-Blatchford, I., Melhuish, Edward, Melhuish, Edward C., Taggart, B   +24 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source