Results 91 to 100 of about 1,145,423 (310)

Impact of beta-lactam antibiotic renal dose adjustment on clinical outcomes in patients with septic shock and acute kidney injury from gram-negative bloodstream infections: a multicenter observational study

CMI Communications
Objective: Beta-lactam antibiotics are the backbone of therapy for critically ill patients with sepsis; however, these patients experience pharmacokinetic changes that alter beta-lactam exposure.
Melissa L. Thompson Bastin, Megan A Rech, Kevin D. Betthauser, Mojdeh S. Heavner, Michelle Horng, Steven M. Lemieux, Mollie Lumpkin, Erin K. McCreary, Michael A. Ruggero, Patrick M. Wieruszewski, Y. Vivian Tsai, Jose Barro, Bhavna Jois, James Mease, Carly Cheng, Emily L. Heil   +15 more
doaj   +1 more source

Econometric Analysis of Foreign Reserves and Some Macroeconomic Variables in Nigeria (1970–2007)∗ [PDF]

, 2009
Countries are showing interest in accumulating foreign reserves to ensure macroeconomic stability. There has been some debate whether to beef up the level of nations’ foreign reserves or make it lower, especially in developing countries like Nigeria ...
Olokoyo, F. O., Osabuohien, E. S. C., Salami, A. O.   +2 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Proposed revision to the Federal Reserve's discount window lending programs [PDF]

The Board of Governors' Regulation A currently authorizes the Federal Reserve Banks to operate three main discount window programs: adjustment credit, extended credit, and seasonal credit.
Brian F. Madigan, William R. Nelson
core  

Secondary Adjustment in Prisons: Prisoners’ Strategies of Influence

Qualitative Sociology Review, 2010
This participant observation research explores and examines the strategies that prisoners use to influence prison officers in an Asian prison setting. Grounded theory methodology is employed in the analysis process. From the study, eight strategies of influence are conceptualised: repetition, distraction, finding excuses, feigning ignorance, false ...
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Public enterprise reform in adjustment lending [PDF]

Specific divestiture dates and institutional public enterprise reform should probably not be a matter of hard conditionality for sectoral adjustment lending.
Nellis, John
core  

Psychological adjustment in cybervictims and cyberbullies in secondary education

Anales de Psicología, 2019
El auge de las agresiones cibernéticas entre estudiantes de secundaria y la importancia de ciertas variables de ajuste psicosocial para la comprensión de este tipo de conducta violenta, tanto en agresores como en víctimas, plantean como objetivo en el presente trabajo analizar el perfil psicosocial de ambos implicados en situaciones de ciberagresión ...
Cañas,Elizabeth, Estévez,Estefanía, Marzo,Juan C, Piqueras,José A   +3 more
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source