Results 121 to 130 of about 4,144,121 (310)

Predicting Discounts of Secondary Market Sovereign Debts [PDF]

open access: yes
This paper assesses the Institutional Investor Country Risk Rating (IICR) to analyze whether secondary market prices are reliable indicators of debt values.
Palac-McMiken, Evanor D.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Secondary Analysis of Audio Data. Technical Procedures for Virtual Anonymization and Pseudonymization

open access: yesForum: Qualitative Social Research, 2005
Qualitative material presented as audio data requires a greater degree of protecting of anonymity than for example textual data. Apart from the verbal content, it carries paraverbal aspects including voice characteristics, thus making it easier to ...
Henning Pätzold
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Being (Almost) a Mathematician: Teacher Identity Formation in Post-Secondary Mathematics

open access: yes, 2009
Within the field of mathematics teacher education, mathematics graduate students have recently become subjects of investigation. While research in this area tends to focus on future schoolteachers, little has been done to examine prospective university ...
Beisiegel, Mary deRaeve
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

How much Competition is a Secondary Market? [PDF]

open access: yes, 2008
In this paper, we build a dynamic equilibrium model of durable goods oligopoly, in which consumers face lumpy costs of transacting in the secondary markets and to which they respond by buying and selling infrequently.
Chen, Jiawei   +2 more
core  

Burnout syndrome in secondary school teachers: A systematic review and meta-analysis

open access: yes, 2019
Secondary school teachers are one of the occupational groups presenting the highest levels of sick leave due to stress in the workplace. This form of stress can cause burnout syndrome, which is characterised by emotional exhaustion, depersonalisation and
Aguayo Estremera, Raimundo   +2 more
core   +1 more source

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