Results 101 to 110 of about 4,144,121 (310)

Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials

, 2004
BACKGROUND: A European (EU) and a North American (NA) placebo-controlled study with interferon beta-1b (IFNB-1b) in secondary progressive multiple sclerosis (SPMS) showed divergent results with regard to their primary outcome of sustained Expanded ...
BOARD, POLMAN C, WEINSHENKER B, THOMPSON AJ, BECKMANN K, MULTIPLE SCLEROSIS TRIAL STEERING COMMITTEE AND INDEPENDENT ADVISORY BOARD, DAHLKE F, NORTH AMERICAN NA SPMS INTERFERON BETA B. IN SECONDARY PROGRESSIVE, MCFARLAND H, EUROPEAN EU SPMS INTERFERON BETA B. IN SECONDARY, POZZILLI, Carlo, KAPPOS L, PROGRESSIVE MULTIPLE SCLEROSIS TRIAL STEERING COMMITTEE AND INDEPENDENT ADVISORY   +12 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Diversity, choice and the quasi-market: An empirical analysis of secondary education policy in England [PDF]

, 2009
This article investigates the extent to which exam performance at the end of compulsory education has been affected by three major education reforms: the introduction of a quasi-market following the Education Reform Act (1988); the specialist schools ...
Taylor, J, Steve Bradley, Bradley, S, Jim Taylor   +3 more
core   +1 more source

Revisiting Classic Qualitative Studies

Forum: Qualitative Social Research, 2005
This paper explores methodological issues regarding the revisiting of "classic" qualitative studies. Classic studies pose particular issues for secondary analysis.
Mike Savage
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Operation Analysis of Soft Switching PWM DC-DC Converter with Secondary Snubber

, 2013
The paper deals with analysis of operation of a soft switching PWM DC-DC full-bridge converter with new energy recovery turn-off snubber on secondary side of high frequency power transformer.Principal equations are derived for individual operation states.
Daniel Trip Nistor, Jaroslav Dudrik, Marcel Bodor   +2 more
core   +1 more source

Progress and Problems of Preserving and Providing Access to Qualitative Data for Social Research—The International Picture of an Emerging Culture

Forum: Qualitative Social Research, 2000
In this paper, I hope to offer a global picture of what is happening in the world of qualitative data archiving. Qualidata is in a strong position to be able to offer this insight as it was the world's first initiative to pioneer preservation of ...
Louise Corti
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evaluation Of Defrost Options For Secondary Coolants In Multi-temperature Indirect Transport Refrigeration: Mathematical Modelling & Sensitivity Analysis

, 2012
This paper describes a mathematical model of the defrost process for a finned-tube air chiller, utilised as a heat exchanger in a secondary loop multi-temperature transport refrigeration system, where an antifreeze mixture is deployed as a sensible ...
Finn, Donal Patrick, Brophy, Barry, Cabello-Portoles, Andreas, Smyth, Shane   +3 more
core   +1 more source