Results 81 to 90 of about 27,569,029 (304)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Strategies in Teaching Secondary Analysis of Qualitative Data
Forum: Qualitative Social Research, 2005 Unlike for quantitative approaches, the published literature on secondary analysis of qualitative data is sparse. Among qualitative researchers there is neither a pervasive culture that exists to encourage the secondary analysis of data nor is there an ...
Louise Corti, Libby Bishop
doaj
Banber Erevani Hamalsarani. Sots'iologiaThis study investigates the potential of protests in contemporary Armenian society. Considering the global rise of social protests evolving into significant social movements worldwide and the ongoing movements in Armenia, it is crucial to investigate ...
Gayane Harutyunyan
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Forum: Qualitative Social Research, 2013 Responding to the need for detailed descriptions of analytical practices in transdisciplinary projects and to showcase a way to use qualitative data in secondary analysis, the authors delineate their respective analytic processes.
Elizabeth Sharp +1 more
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Uses of Sociology for Real-time History
Forum: Qualitative Social Research, 2005 This paper was transcribed from a talk presented by David KYNASTON at a seminar on Social Science Data Archives for Social Historians: creating, depositing and using qualitative data, organised jointly by the Economic and Social Data Service (ESDS) and ...
David Kynaston
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FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Data reusability for migration research: a use case from SoDaNet data repository
Frontiers in Human DynamicsThis study highlights the role of Research Data Repositories (RDRs) in the concept of data reuse by examining a use case on migration research, a domain that requires up-to-date and accurate data for research and policy purposes.
Dimitra Kondyli +4 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source