Results 151 to 160 of about 8,095,731 (348)

Association between P-Pulmonale and Respiratory Morbidity in COPD: a Secondary Analysis of the BLOCK-COPD trial [PDF]

open access: green, 2023
R. Chad Wade   +10 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

334P: Outcomes according to dosimetric factors: A secondary analysis of CALGB 30610 (Alliance)/RTOG 0538 (NRG) [PDF]

open access: bronze
M. Mix   +15 more
openalex   +1 more source

Secondary Analysis in Exploring Family and Social Change: Addressing the Issue of Context

open access: yesForum: Qualitative Social Research, 2005
This paper explores the issue of context in conducting secondary analysis and draws out the particular epistemological, methodological, practical and ethical challenges associated with the re-use of historically specific, contextually bound archived ...
Val Gillies, Rosalind Edwards
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

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