Results 121 to 130 of about 80,021 (260)

Arcuate nucleus-specific progesterone receptor knockdown in female mice is sufficient to induce PCOS-like hyperactivity in the reproductive axis. [PDF]

J Neuroendocrinol
Glendining KA, Prescott M, Potapov K, Kip E, Campbell RE.   +4 more
europepmc   +1 more source

In Situ Characterisation of Hydrogels via Dynamic Interface Printing

Advanced Science, EarlyView.
ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler, Michael Halwes, David J. Collins   +2 more
wiley   +1 more source

Safety concerns associated with high-dose continuous infusion of cefepime among critically ill patients with mild renal impairment to augmented renal clearance at a level 1 trauma center: CEFTOX study. [PDF]

Antimicrob Agents Chemother
Lamamri M, Rutman C, Codorniu A, Holleville M, Sigaut S, Weiss E, Jeantrelle C.   +6 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

A retroelement-derived mammalian ARC protein exhibits selective RNA recognition and nucleic acid chaperone functions. [PDF]

Nucleic Acids Res
Gumna-Mikina J, Andrzejewska-Romanowska A, Antczak M, Tykwińska E, Szachniuk M, Pachulska-Wieczorek K.   +5 more
europepmc   +1 more source

Single‐Atom Pt Anchoring on Self‐Doped ZrO2@G‐C3N4 Nanostructure Enables Efficient Photocatalytic Seawater Hydrogen Evolution

Advanced Science, EarlyView.
Grain‐like Zr3+‐ZrO2 and Pt single atoms are integrated into an S‐scheme Zr3+‐ZrO2@g‐C3N4 heterostructure to enable efficient visible‐light‐driven seawater hydrogen production. The combined effect of Pt single‐atom sites and the S‐scheme charge‐transfer pathway accelerates carrier separation, preserves strong redox ability, and markedly enhances ...
Hezheng Sun, Yifan Guo, Xin Yu, Yajie Tian, Feng Gao, Bin Wang, Yanting Tang, Dani S. Assi, Vellaisamy A. L. Roy   +8 more
wiley   +1 more source

Climate Action Impacts on Steelmaking Emissions of Persistent Organic Pollutants Highlight a Gap Between the Paris Agreement and the Stockholm Convention

Advanced Science, EarlyView.
Emissions of unintentionally produced persistent organic pollutants (UPOPs) and global warming are two major environmental challenges. But their governance has largely evolved in parallel, leaving the toxicity implications of climate‐driven industrial transitions poorly understood.
Yuxiang Sun, Qiuting Yang, Jianghui Yun, Yujue Yang, Junhao Tang, Qian Liu, Minghui Zheng, Guorui Liu   +7 more
wiley   +1 more source

Effects of fermented versus unfermented red cabbage on symptoms, immune response, inflammatory markers and the gut microbiome in young adults with allergic rhinoconjunctivitis: a randomised controlled trial protocol. [PDF]

BMJ Open
Ngoumou GB, Ngandeu Schepanski S, Blakeslee SB, Diedering A, Twal E, Raue SL, Schroeder M, Wicaksono WA, Stritter W, Berg G, Seifert G.   +10 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Mesenteric Steal Syndrome Caused by Abdominal Aortic Stenosis due to Takayasu Arteritis. [PDF]

Surg Case Rep
Nagashima S, Inoue K, Fujioka Y, Ueno K, Kinoshita G, Yoshino S, Morisaki K, Yoshizumi T.   +7 more
europepmc   +1 more source