Results 61 to 70 of about 1,821,903 (265)

Fatores associados à insatisfação dos usuários dos centros de especialidades odontológicas do Brasil em 2014: estudo transversal

Epidemiologia e Serviços de Saúde
Resumo Objetivo avaliar os fatores associados à insatisfação dos usuários dos centros de especialidades odontológicas (CEOs) do Brasil. Métodos estudo transversal, com dados do Programa de Melhoria do Acesso e da Qualidade dos CEOs; realizado em 2014,
Fabíola Bof de Andrade, Rafaela da Silveira Pinto   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of a follow-up visit on two-year mortality after severe exacerbation of COPD in Finland

European Clinical Respiratory Journal
Background While guidelines recommend follow-up visits after an acute exacerbation of COPD (AECOPD), the optimal healthcare facility, timing and its effect on long-term mortality are not well known.Methods In this retrospective case–control study ...
Tanja Törölä, Paula Kauppi, Witold Mazur, Miika Linna, Jaana Keto   +4 more
doaj   +1 more source

Patients’ and healthcare professionals’ views on a specialist smoking cessation service delivered in a United Kingdom hospital: a qualitative study

Tobacco Induced Diseases, 2014
Background Hospital admission provides a powerful opportunity to promote smoking cessation. We explored patients’ and healthcare professionals’ (HCP) views of a specialist smoking cessation service comprising systematic smoking ascertainment, default ...
Manpreet Bains, John Britton, John Marsh, Leah Jayes, Rachael L Murray   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Changes in smoking prevalence and cessation support, and factors associated with successful smoking cessation in Swedish patients with asthma and COPD

European Clinical Respiratory Journal, 2018
Introduction: Our aim was to investigate changes in smoking prevalence, smoking cessation support and factors associated with successful smoking cessation in patients with asthma and COPD.
Marcus Stegberg, Mikael Hasselgren, Scott Montgomery, Karin Lisspers, Björn Ställberg, Christer Janson, Josefin Sundh   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Rheumatic conditions associated with interstitial lung diseases: real-world outcomes in a secondary care setting

Monaldi Archives for Chest Disease
Management of rheumatic conditions associated with interstitial lung disease (r-ILD) requires expertise, often occurring in tertiary referral centers.
Alex Francioni, Muhammad K Nisar, Natasha Ramsundar, Vijay Joshi, Judeson Gnanapragasam   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Clinical referral to the NHS following multi-cancer early detection test results from the NHS-Galleri trial

Frontiers in Oncology
IntroductionThe large, randomised, controlled NHS-Galleri trial (NCT05611632) is assessing the clinical utility of a multi-cancer early detection (MCED) test for asymptomatic cancer screening in England.
Ian Lowenhoff, Saoirse Dolly, Rebecca Dowinton Smith, Sara Hiom, Liz Holmes, Peter Johnson, Laura King, Richard D. Neal, Thomas Round, Charles Swanton, Charles Swanton, Lennard Y. W. Lee, Lennard Y. W. Lee   +12 more
doaj   +1 more source