Results 121 to 130 of about 3,135,634 (302)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Homogenization of initial cell distribution by secondary flow of medium improves cell culture efficiency. [PDF]

PLoS One, 2020
Fukuma Y, Inui T, Imashiro C, Kurashina Y, Takemura K.   +4 more
europepmc   +1 more source

Viscous analyses for flow through subsonic and supersonic intakes [PDF]

A parabolized Navier-Stokes code was used to analyze a number of diffusers typical of a modern inlet design. The effect of curvature of the diffuser centerline and transitioning cross sections was evaluated to determine the primary cause of the flow ...
Povinelli, Louis A., Towne, Charles E.
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

The evolution of secondary flow phenomena and their effect on primary shock conditions in shock tubes: Experimentation and numerical model. [PDF]

PLoS One, 2020
Kahali S, Townsend M, Mendez Nguyen M, Kim J, Alay E, Skotak M, Chandra N.   +6 more
europepmc   +1 more source

Evaluation of seals for high-performance cryogenic turbomachines [PDF]

An approach to computing flow and dynamic characteristics for seals or bearings is discussed. The local average velocity was strongly influenced by inlet and exit effects and fluid injection, which in turn drove zones of secondary flow.
Braun, M. J., Hendricks, R. C., Tam, L. T., Vlcek, B. L.   +3 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

An Improved Physical Model for Open Channel Confluences: Bridging the Gap Between Laboratory and Field Observations

Water Resources Research
Despite decades of research on hydro‐morphodynamic processes at open‐channel confluences, significant discrepancies persist between flume experiments and field observations.
Keyu Li, Qingcheng Yu, Xudong Ma, Lu Wang, Ruihua Nie   +4 more
doaj   +1 more source

Nonlinear Grtler Vortices and Their Secondary Instability in a Hypersonic Boundary Layer [PDF]

Nonlinear development of the Grtler instability over a concave surface gives rise to a highly distorted inflectional flow field in the boundary layer that leads to both wall-normal and spanwise gradients in the flow.
Choudhari, Meelan M., Li, Fei, Paredes, Pedro   +2 more
core   +1 more source