Results 101 to 110 of about 1,385,615 (259)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
On vortex/wave interactions. Part 1. Non-symmetrical input and cross-flow in boundary layers
, 1996 The paper studies certain effects of non-symmetry on vortex/wave interactions, for inviscid inflexional waves interacting nonlinearly with the vortex component of the mean flow in boundary-layer transition at large Reynolds number.
Brown, SN, Smith, FT
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Secondary flow phenomena in a rotating radial straight square channel
, 1996 Flow visualization results for secondary flow phenomena near the exit of a rotating radial straight square channel are presented to study Coriolis instability phenomena (formation of Coriolis vortices) and early laminar-turbulent transition for ...
Wang, L, Cheng, KC
core
The effects of end wall profiling on secondary loss is a turbine nozzle row [PDF]
, 2000 This thesis presents detailed investigations of the effect of end wall profiling on the secondary loss in a turbine nozzle row. The purpose of this project was to obtain a detailed view of the flow structure downstream of the blade passage, especially of
Gkiouvetsis, Adamntois
core
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
SECONDARY FLOW IN A STRAIGHT OPEN CHANNEL
, 1993 It is well known that the secondary flow can be observed in a straight open channel, however, it is elusive to be detected because of its small magnitude and unstableness.
今本, 博健 +2 more
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source