Results 81 to 90 of about 1,385,615 (259)
Numerical modelling of viscous turbomachinery flows with a pressure correction method [PDF]
, 1992 A fully elliptic computational method for the analysis of steady viscous flow in high speed subsonic centrifugal compressor impellers with tip leakage, is presented.
Tourlidakis, A.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Characterization of the secondary flow in turbulent rectangular ducts with varying aspect ratio
, 2015 Direct numerical simulations of turbulent duct flows with width-to-height ratios 1, 3, 5, 7 and 10, at a friction Reynolds number Reτ,c, 180, are carried out with the spectral element code Nek5000. The aim of these simulations is to gain insight into the
Vinuesa, Ricardo, +2 more
core
Influence of corner geometry on the secondary flow in turbulent square ducts
, 2017 Direct numerical simulations of fully-developed turbulent flow through a straight square duct with increasing corner rounding radius r were performed to study the influence of corner geometry on the secondary flow. Unexpectedly, the increased rounding of
R. Vinuesa +7 more
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Automated Extraction of Secondary Flow Features
, 2005 The use of Computational Fluid Dynamics (CFD) has become standard practice in the design and development of the major components used for air and space propulsion. To aid in the post-processing and analysis phase of CFD many researchers now use automated
Dorney, Suzanne M. +3 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
On the secondary flow through bifurcating pipes
, 2010 The secondary motion induced by flow through curves and bifurcations has been subject to investigation over long time due to its importance in physiological and technological applications.
Laszlo Fuchs +5 more
core +1 more source