Results 131 to 140 of about 3,130,306 (355)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Turbulence Model Constant Calibration for Flow Field in Rod Bundle Based on Data Assimilation
Yuanzineng kexue jishuThe paper presents a novel approach to enhancing the accuracy of turbulence modeling in nuclear reactor simulations, specifically addressing secondary flow in the fuel assembly of pressurized water reactors.
LI Yi, QU Wenhai, XIONG Jinbiao
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Homogenization of initial cell distribution by secondary flow of medium improves cell culture efficiency. [PDF]
PLoS One, 2020 Fukuma Y +4 more
europepmc +1 more source
Evaluation of seals for high-performance cryogenic turbomachines [PDF]
An approach to computing flow and dynamic characteristics for seals or bearings is discussed. The local average velocity was strongly influenced by inlet and exit effects and fluid injection, which in turn drove zones of secondary flow.
Braun, M. J. +3 more
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
The evolution of secondary flow phenomena and their effect on primary shock conditions in shock tubes: Experimentation and numerical model. [PDF]
PLoS One, 2020 Kahali S +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Viscous analyses for flow through subsonic and supersonic intakes [PDF]
A parabolized Navier-Stokes code was used to analyze a number of diffusers typical of a modern inlet design. The effect of curvature of the diffuser centerline and transitioning cross sections was evaluated to determine the primary cause of the flow ...
Povinelli, Louis A., Towne, Charles E.
core +1 more source
Secondary vortex-based analysis of flow characteristics and pressure drop in helically coiled pipe [PDF]
, 2017 Lingdi Tang +3 more
openalex +1 more source