Results 41 to 50 of about 1,385,615 (259)
, 2022 Direct numerical simulations of a turbulent channel flow developing over convergent-divergent (C-D) riblets at a Reynolds number of Reb = 2800 are presented.
郭同彪 +4 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Experiments in a turbine cascade for the validation of turbulence and transition models [PDF]
, 1995 This thesis presents a detailed investigation of the secondary flow and boundary layers in a large scale, linear cascade of high pressure turbine rotor blades.
Moore, H, H. Moore
core
Secondary instability of separated shear layers. [PDF]
, 2018 The process through which a laminar flow undergoes transition to turbulence is of great fundamental and practical interest. Such a process is hugely complex as there are many diverse routes for a laminar flow to become turbulent flow.
Yang, Zhiyin
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Enhanced Drag in Pipe Turbulent Flow by an Aqueous Electrolyte: an Electroviscous Effect [PDF]
, 2009 Drag enhancement is reported for turbulent pipe flow of aqueous electrolyte solutions. No electroviscous effect was obtained with laminar flow. Nor was any unusual pressure drop observed for laminar or turbulent flow of non-electrolyte aqueous solutions ...
Chen, John J. J. +8 more
core +1 more source
Contribution of Reynolds-stress structures to the secondary flow in turbulent ducts [PDF]
, 2019 The present work is aimed at evaluating the contribution to the secondary flow in duct flow with square and rectangular cross section from three-dimensional coherent structures, defined as intense Reynolds-stress events.
Atzori, Marco, +3 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source