Results 51 to 60 of about 1,385,615 (259)
Reprint of: Influence of corner geometry on the secondary flow in turbulent square ducts
, 2017 Direct numerical simulations of fully-developed turbulent flow through a straight square duct with increasing corner rounding radius r were performed to study the influence of corner geometry on the secondary flow. Unexpectedly, the increased rounding of
Nagib, H. M., +7 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 2019 Purpose: The study aims to focus on rotation effects on a ribbed channel of gas turbine blades for internal cooling. The combination and interaction between secondary flows generated by angled rib geometry and Coriolis forces in the rotating channel are ...
Hoseinalipour, Seyyed Mostafa, +4 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Application of Non-Axisymmetric Endwall Contouring in a 1½ Stage, Rotating Turbine [PDF]
, 2011 Today gas turbines are a crucial part of the global power generation and aviation industries. Small improvements to the efficiencies of individual components within the gas flow path can, over time, lead to dramatic cost savings for the operator and at ...
SNEDDEN, GLEN,CAMPBELL +1 more
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, 2017 In this paper, we proposed a microparticle manipulation approach, by which particles are able to be guided to different equilibrium positions through modulating the Reynolds number. In the microchannel with arc-shaped groove arrays, secondary flow vortex
Zhao, Qianbin +13 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2001 This paper introduced a new application of pattern recognition technique to the problem of automatic identification of secondary flow patterns in a heated curve rectangular channels. The proposed algorithm is based on two observations.
Chandratilleke, T. +3 more
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