Results 71 to 80 of about 132,148 (255)

Efficacy and safety of pharmacological and non-pharmacological therapies in Lennox-Gastaut syndrome: a systematic review and network meta-analysis

Frontiers in Pharmacology
ObjectiveThis study aimed to evaluate the efficacy and safety of antiepileptic drugs and non-pharmacological treatments in patients with Lennox-Gastaut syndrome (LGS).MethodsWe conducted a systematic search of the PubMed, Embase, Cochrane, and Web of ...
Zhengyan Zhu, Zhengyan Zhu, Zhenpan Zhang, Zhenpan Zhang, Wei Xiao, Wei Xiao, Wei Xiao, Chunhua Wang, Chunhua Wang, Risheng Liang, Risheng Liang   +10 more
doaj   +1 more source

Research on fast response criterion of power grid distributed loads after HVDC block fault

IET Generation, Transmission & Distribution, 2020
The system equivalent inertia of the power grid is gradually decreased with the increasing penetration of renewable energy resources, which leads to a higher risk of frequency fluctuation after a major fault.
Yuling Wang, Wannan Zhang, Haishun Sun, Yingmeng Xiang, Di Shi, Zhiwei Wang   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Primary frequency control of DFIG-WTs using bang-bang phase angle controller [PDF]

, 2018
A bang-bang phase angle controller (BPAC) was proposed in this study for the primary frequency control of doublyfed induction generator-based wind turbines (DFIG-WTs). Dynamics of the internal voltage of a synchronous generator (SG) and that of a DFIG-WT
Liu, Y, Q. H. Wu, Wu, QH, Lin Jiang, Jeremy S. Smith, Jiang, L, Jiang, Lin, Smith, Jeremy S, Liu, Yang, Yang Liu, Smith, JS   +10 more
core   +1 more source

An optimal stepwise inertial control strategy for wind turbines based on improved fuzzy adaptive control

Zhejiang dianli
Conventional stepwise inertial control （SIC） is decoupled from grid frequency， which limits the real-time frequency perception of wind turbines and may lead to severe secondary frequency drop （SFD）.
ZHOU Tao, YAO Jiachen, NI Jun, XU Chao, XU Yan   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Influence of Secondary Impact on Printed Wiring Assemblies—Part II: Competing Failure Modes in Surface Mount Components [PDF]

, 2017
Portable electronic devices are commonly exposed to shock and impact loading due to accidental drops. After external impact, internal collisions (termed “secondary impacts” in this study) between vibrating adjacent subassemblies of a product may occur if
Jingshi Meng, Abhijit Dasgupta
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Design of a novel vortex-based feedback fluidic oscillator with numerical evaluation

Engineering Applications of Computational Fluid Mechanics, 2020
In this study, a new vortex-based fluidic oscillator was designed whose performance was numerically evaluated by solving the URANS equations. The oscillator consists of a primary chamber and secondary chamber, separated by a mid-throat and connected by ...
Mahdi Nili-Ahmadabadi, Dae-Seung Cho, Kyung Chun Kim   +2 more
doaj   +1 more source