Results 71 to 80 of about 6,211,757 (240)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A robust fault detection method of rolling bearings using modulation signal bispectrum analysis [PDF]
, 2015 Envelope analysis is a widely used method for bearing fault detection. To obtain high detection accuracy, it is critical to select an optimal narrowband for envelope demodulation.
Gu, Fengshou +4 more
core +4 more sources
CSEE Journal of Power and Energy SystemsPower inverter adopting virtual synchronous generator (VSG) control can provide inertia support for distributed generation systems. However, it cannot take into account the dynamic regulation characteristics of frequency. Thus, when the system encounters
Hongwei Fang, Zhiwei Yu
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Area spectral efficiency of soft-decision space–time–frequency shift-keying-aided slow-frequency-hopping multiple access [PDF]
, 2012 Slow-frequency-hopping multiple access (SFHMA) can provide inherent frequency diversity and beneficially randomize the effects of cochannel interference.
Ngo, Hoang Anh +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Novel Jamming Method Based on Sine Function Secondary Modulation and Phase Coded Modulation
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingWith the development of synthetic aperture radar (SAR) imaging technology, the research of SAR jamming method has become an important topic in the field of electronic countermeasures.
Guikun Liu +8 more
doaj +1 more source
Evaluating the Spectrum of Unlocked Injection Frequency Dividers in Pulling Mode
Entropy, 2013 We study the phenomenon of periodic pulling which occurs in certain integrated microcircuits of relevant interest in applications, namely the injection-locked frequency dividers (ILFDs). They are modelled as second-order driven oscillators working in the
Alessandro Lo Schiavo, Antonio Buonomo
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source