Results 131 to 140 of about 358,984 (291)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Unified centralized/decentralized voltage and frequency control structure for microgrids [PDF]

The centralized secondary control strategies for microgrids (MG) are widely used due to their ease of control and coordination with distributed resources.
GODOY, Paulo Thiago de
core  

Event-Triggered Communication Mechanism for DRL Secondary Frequency Compensation in AC Islanded Microgrid [PDF]

Frequency deviation challenges the stable operation of AC islanded microgrids, and the development of machine learning-based control schemes offer a new solution to this problem. This paper proposes a deep reinforcement learning (DRL) secondary frequency
Anvari-Moghaddam, Amjad; id_orcid, Li, Sijia, Blaabjerg, Frede; id_orcid   +2 more
core   +1 more source

Learning-based flexible load aggregation for secondary frequency regulation in co-simulated transmission and distribution networks

International Journal of Electrical Power & Energy Systems
Aggregated flexible loads offer a promising solution for secondary frequency regulation (SFR) in power systems with increasing intermittent renewable energy sources.
Mengtong Chen, Qinran Hu, Tao Qian, Xinyi Chen, Rushuai Han, Yongxu Zhu   +5 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

A Cooperative Game Theory-based Secondary Frequency Regulation in Distribution Systems

2021 North American Power Symposium (NAPS), 2021
Mukesh Gautam, Narayan Bhusal, Mohammed Benidris, Hanif Livani   +3 more
openaire   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Secondary Frequency and Voltage Regulation of dVOC-Based Microgrids Based on Distributed Model Predictive Control

Energies
In order to address the challenges of frequency fluctuations and uneven voltage distributions in islanded microgrids, this paper proposes a distributed model predictive control (DMPC) strategy for secondary frequency and voltage regulation, and it adopts
Yushuo Cao, Yuheng Gao, Guanguan Zhang, Jianchao Wang, Cheng Fu, Shaokun Niu   +5 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Energy Storage Multi-Stage Dynamic Frequency Modulation Control Strategy Based on Inertia–Damping Coordination Tuning

Energies
High renewable penetration reduces system inertia and limits frequency support capability. Conventional energy storage systems using fixed inertia–damping virtual synchronous generator control cannot adapt to the multi-stage characteristics of frequency ...
Ning Zhang, Li Zhang, Xijun Ren, Jia Dong, Lianchao Liu, Dong Han   +5 more
doaj   +1 more source