Results 161 to 170 of about 2,804,350 (243)

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

open access: yesComprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond   +6 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Ameliorate NaIO3‐Induced Dry AMD by Delivering miR‐486‐3p to Inhibit Lipocalin‐2‐Mediated Ferroptosis

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li   +6 more
wiley   +1 more source

An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts

open access: yesChemistryOpen, Volume 15, Issue 10, October 2026.
S. heldreichiana and S. tomentosa can be considered as effective sources of natural bioactive agents for further in vivo pharmacological evaluation and development. The genus Salvia, widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses.
Gokhan Zengin   +9 more
wiley   +1 more source

Effectiveness of Telehealth Low‐Carbohydrate Intervention in Preventing Chronic Kidney Disease: A Real‐World, Retrospective, Matched Cohort Study

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9054-9068, October 2026.
ABSTRACT Background Lifestyle interventions targeting metabolic health may influence chronic kidney disease (CKD) risk, particularly among adults with type 2 diabetes and obesity. We evaluated real‐world associations between a telehealth‐delivered, individualized nutrition therapy program (VINT) and CKD incidence and progression compared with usual ...
Shaminie J. Athinarayanan   +7 more
wiley   +1 more source

PEBP1 Regulates Ferroptosis in Acute Glaucoma: Targeted Therapy Using Engineered Exosomes

open access: yesThe FASEB Journal, Volume 40, Issue 17, 15 September 2026.
General schematic diagram of Spatial and Single‐Cell Transcriptomics Identifies PEBP1 as a Ferroptosis Mediator in Glaucoma: Targeted Intervention by Engineered Stem Cell Exosomes. ABSTRACT Glaucoma is the leading cause of irreversible blindness worldwide, primarily driven by the progressive loss of retinal ganglion cells (RGCs) under pathological high
Yijia Huang   +13 more
wiley   +1 more source

Factors associated with the avoidance of glaucoma surgery in secondary glaucoma due to ocular inflammatory disease. [PDF]

open access: yesJ Ophthalmic Inflamm Infect
Nishio Y   +6 more
europepmc   +1 more source

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