Results 201 to 210 of about 2,804,350 (243)

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

open access: yesNeuroprotection, Volume 4, Issue 3, Page 275-294, September 2026.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu   +13 more
wiley   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

open access: yesObesity, Volume 34, Issue S2, Page 75-87, September 2026.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu   +13 more
wiley   +1 more source

Comprehensive Chemical and Biological Assessment of Orobanche racemosa Extracts Using Chromatographic, In Vitro, In Silico, and Cell‐Based Techniques

open access: yesChemistryOpen, Volume 15, Issue 9, September 2026.
Orobanche racemosa can be considered an effective source of natural bioactive agents in designing functional applications. The growing interest in natural product research as a safer and sustainable alternative to synthetic drugs has triggered this study, which evaluates the chemical profile and biological activity of Orobanche racemosa extracts.
Nilofar Nilofar   +13 more
wiley   +1 more source

Artificial intelligence‐enabled cytopathological interpretation of fluorescence microscopy images via a multimodal large language model

open access: yesQuantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Quantitative analysis of fluorescence microscopy images remains a significant challenge in cytopathological assessments, as subjective interpretation and inter‐observer variability hinder reproducibility and standardization of classifications. In this study, an artificial intelligence‐assisted analytical framework utilizing a multimodal large ...
Atakan Tevlek   +2 more
wiley   +1 more source

Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP‐Like Phenotype After Glaucoma Filtration Surgery

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
Transcriptomic analysis using a rabbit glaucoma filtration surgery model, combined with in vitro experiments on human conjunctival fibroblasts, demonstrates that mitomycin C induces a senescence‐associated secretory phenotype (SASP)‐like state. These SASP‐like fibroblasts were selectively eliminated by the specific senolytic agent, highlighting their ...
Akitoshi Kimura   +12 more
wiley   +1 more source

Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative mode of telomere replication. ABSTRACT Cell division inevitably shortens telomeric DNA owing to the end‐replication problem.
Jie Wang   +8 more
wiley   +1 more source

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