Combining single-cell RNA sequencing with spatial transcriptome analysis reveals dynamic molecular maps of cambium differentiation in the primary and secondary growth of trees. [PDF]
Plant Commun, 2023 Li R, Wang Z, Wang JW, Li L.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The dynamic and diverse nature of parenchyma cells in the Arabidopsis root during secondary growth. [PDF]
Nat PlantsLyu M +10 more
europepmc +2 more sources
The Effects of Secondary Growth of Spartina alterniflora after Treatment on Sediment Microorganisms in the Yellow River Delta. [PDF]
Microorganisms, 2022 Shang S +8 more
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
CRACK GROWTH SIMULATION BASED ON ABAQUS SECONDARY EVELOPMENT
Jixie qiangdu, 2018 Crack propagation is a typical discontinuous problem, which is difficult to be simulated with traditional finite element method. In order to solve the defects of traditional methods, extended finite element method introduced level set function method to ...
ZHANG WenDong +3 more
doaj
Transcription factor NTL9 negatively regulates Arabidopsis vascular cambium development during stem secondary growth. [PDF]
Plant Physiol, 2022 Sugimoto H +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Gibberellin Signaling Promotes the Secondary Growth of Storage Roots in Panax ginseng. [PDF]
Int J Mol Sci, 2021 Hong CP +11 more
europepmc +1 more source