Results 91 to 100 of about 1,508,558 (264)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Tuberculosis among community-based health care researchers. [PDF]

, 2010
BACKGROUND: Occupational tuberculosis (TB) in hospital-based health care workers is reported regularly, but TB in community-based health care researchers has not often been addressed. OBJECTIVE: To investigate TB incidence in health care researchers in a
Godfrey-Faussett, P, Claassens, MM, Sismanidis, C, Enarson, DA, Lawrence, K-A, Beyers, N, Ayles, H   +6 more
core  

A cluster randomized controlled trial of the effectiveness and cost-effectiveness of Intermediate Care Clinics for Diabetes (ICCD) : study protocol for a randomized controlled trial [PDF]

, 2012
Background World-wide healthcare systems are faced with an epidemic of type 2 diabetes. In the United Kingdom, clinical care is primarily provided by general practitioners (GPs) rather than hospital specialists.
Joseph Paul O’Hare, Saravanan, Ponnusamy, Baker Richard, Baines Darrin, O’Hare, J.P., Khunti, Kamlesh, Crossman, R., Andrew Wilson, Saravanan, P., Hardy, Ainsley, Davies Melanie, Armstrong, Natalie, O’Hare Joseph, Ala Szczepura (83137), Darrin Baines (552528), Raymond, N., Saravanan Ponnusamy, Sudhesh Kumar (89490), Kumar, S., Richard Crossman (7674521), Stallard, N., Andrew Wilson (23322), Khunti Kamlesh, Kamlesh Khunti, Davies, Melanie, Armstrong, N., Wilson Andrew, Baker, Richard H., Natalie Armstrong, Hardy Ainsley, Crossman, Richard, Ala Szczepura, Hardy, A., Wilson, Andrew, Richard Baker, Darrin Baines, Ponnusamy Saravanan (552529), Raymond Neil, Melanie Davies (545715), Raymond, Neil T., HASH(0x55a68055b430), Richard Baker (301808), Baines, Darrin L., Ainsley Hardy, Ainsley Hardy (552526), Kumar Sudhesh, Baker, R., Stallard, Nigel, Nigel Stallard, Stallard Nigel, Sudhesh Kumar, Baines, Darrin, Melanie Davies, Neil T. Raymond (5504591), Davies, M., Natalie Armstrong (7594022), Neil Raymond, Joseph Paul O'Hare (7674524), Szczepura, Ala; id_orcid, Szczepura, Ala, Richard Crossman, Wilson, A., Kumar, Sudhesh, Kamlesh Khunti (171607), Nigel Stallard (3186006), Szczepura Ala, Khunti, K., Crossman Richard, Armstrong Natalie, O'Hare, J. Paul, Ponnusamy Saravanan   +70 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of removing direct payment for health care on utilisation and health outcomes in Ghanaian children: a randomised controlled trial. [PDF]

, 2009
BACKGROUND: Delays in accessing care for malaria and other diseases can lead to disease progression, and user fees are a known barrier to accessing health care. Governments are introducing free health care to improve health outcomes.
Greenwood, Brian M, Vivian Dzordzordzi, Kakra Dickson, Mills, Anne, John Owusu Gyapong, Evelyn Korkor Ansah, Kingsley Biantey, Biantey, Kingsley, Christopher J M Whitty, Ansah, Evelyn Korkor, Asiamah, Sabina, Koram, Kwadwo Ansah, Dzordzordzi, Vivian, Narh-Bana, Solomon, Sabina Asiamah, Brian M Greenwood, Gyapong, John Owusu, Anne Mills, Whitty, Christopher JM, Solomon Narh-Bana, Dickson, Kakra, Kwadwo Ansah Koram   +21 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The Effect of Distance to Formal Health Facility on Childhood Mortality in Rural Tanzania, 2005-2007. [PDF]

, 2012
Major improvements are required in the coverage and quality of essential childhood interventions to achieve Millennium Development Goal Four (MDG 4). Long distance to health facilities is one of the known barriers to access. We investigated the effect of
Mathew, Alexander, Masanja, H, Masanja, Honorati, Sartorius, B, Kadobera, Daniel, Waiswa, P,, Sartorius, Benn, Mathew, A, Kadobera, D, Waiswa, Peter   +9 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source