Results 81 to 90 of about 3,127,419 (312)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Access to HIV care in the context of universal test and treat: challenges within the ANRS 12249 TasP cluster-randomized trial in rural South Africa [PDF]

, 2016
Introduction: We aimed to quantify and identify associated factors of linkage to HIV care following home-based HIV counselling and testing (HBHCT) in the ongoing ANRS 12249 treatment-as-prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal ...
Attia, Barnabas, Bassett, Cohen, Collins Iwuji, Danel, Doherty, Donnell, Fox, France Lert, François Dabis, Granich, Hatcher, Houlihan, Iwuji, Joanna Orne-Gliemann, Joseph Larmarange, Kamal El Farouki, Lundgren, MacPherson, Maheswaran, Marie-Louise Newell, Medley, Morris, Mugglin, Muloongo, Mélanie Plazy, Naik, Naik, Nakigozi, Nonhlanhla Okesola, Nsigaye, Orne-Gliemann, Rooyen, Rosemary Dray-Spira, Rosen, Tabana, Tanser, Wringe, Zaidi   +39 more
core   +6 more sources

Abortion care in Haiti: A secondary analysis of demographic and health data

PLOS ONE, 2018
Abortion-related mortality accounts for 8% of all global maternal deaths and 97% of the estimated 25 million unsafe abortions performed each year occur in low- and middle-income countries. Haiti has the highest rate of maternal mortality in the western hemisphere and to further understand the circumstances of induced abortion in Haiti, the current work
Kate Meffen, Gillian Burkhardt, Susan Bartels   +2 more
openaire   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Young People's mental health service utilization

International Journal of Population Data Science
Objective This project aimed to uncover key factors that shape young people’s (YP) mental health care utilization. The Andersen’s Behavioral Model of Health Care Utilization was adapted in co-production, providing a framework for the predisposing ...
Corine Driessens, Peter W.F. Smith, Kim Markham-Jones, Fiona Lacey   +3 more
doaj   +1 more source

Quality of outpatient nursing care: a scoping review [PDF]

Revista Latino-Americana de Enfermagem
Objective: to map national and international scientific literature on the quality of outpatient nursing care. Method: a scoping review guided by the Joanna Briggs Institute Collaboration, conducted across 12 databases and repositories.
Bruna Noschang de Brum, Carlise Rigon Dalla Nora, Adriana Roese Ramos, Luciana Foppa, Deise Lisboa Riquinho   +4 more
doaj   +1 more source

Case management for the treatment of patients with major depression in general practices – rationale, design and conduct of a cluster randomized controlled trial – PRoMPT (primary care monitoring for depressive patient's trial) [ISRCTN66386086] – Study protocol [PDF]

, 2005
Background: Depression is a disorder with high prevalence in primary health care and a significant burden of illness. The delivery of health care for depression, as well as other chronic illnesses, has been criticized for several reasons and new ...
Jochen Gensichen, Marion Torge, Monika Peitz, Heike Wendt-Hermainski, Martin Beyer, Thomas Rosemann, Christian Krauth, Heiner Raspe, Josef B Aldenhoff, Ferdinand M Gerlach, J Ormel, J Ormel, D Kamerow, T Ustun, A Shah, G Simon, T Bodenheimer, B Ahrens, J Fritze, A Coulter, T Os van, M Von Korff, S Norris, S Gilbody, J Gensichen, MK Campbell, MK Campbell, B Löwe, RJ Hayes, S Banerjee, MK Campbell, A Beck, D Moriskey, M Bullinger, EuroQOL-Group   +34 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A construção do aprendizado no Sistema de Saúde: visão dos acadêmicos de medicina

Revista Educação em Saúde, 2012
This paper is an experience report of the Integration Program in Family Health Strategy (PIESF) of UniEVANGÉLICA's Medical School, conducted by the students who attended the program between 2008 and 2011. The aim of this study was to introduce the PIESF
Dayse Vieira Santos Barbosa, Eduardo de Castro, Mariana Vilela de Castro, Natália Vieira Dias, Sara Rezende Carvalho   +4 more
doaj  

The Philippine Health Institutions: Some Problems, Approaches and Policy Issues [PDF]

This paper presents a brief analysis of the current situation of Philippine health institutions using secondary data. It locates the different types of health institutions, describes its major problems, discusses recent approaches these institutions have
Chiong-Javier, Maria Elena, Ramos-Jimenez, Pilar   +1 more
core