Results 81 to 90 of about 17,597,372 (253)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Informações da atenção secundária em Odontologia para avaliação dos modelos de atenção à saúde

Revista de Odontologia da UNESP
INTRODUÇÃO: Considerando-se o princípio da integralidade e a construção das redes de atenção no Sistema Único de Saúde, a atenção secundária pode refletir a resolutividade da atenção básica, apoiando a organização das ações e dos serviços de saúde bucal ...
Jaqueline Vilela Bulgareli, Eduardo Tanajura de Faria, Gláucia Maria Bovi Ambrosano, Fabiana de Lima Vazquez, Karine Laura Cortellazzi, Marcelo de Castro Meneghim, Fábio Luiz Mialhe, Antonio Carlos Pereira   +7 more
doaj  

Exploratory thresholds for ambient PM2.5 constituents in relation to blood pressure levels in Chinese children

BMC Public Health
Background This study aimed to examine the associations of fine particulate matter (PM2.5) constituents and their interactions with meteorological factors with blood pressure (BP) among Chinese school-aged children, to inform targeted protection ...
Junyi Wang, Xijie Wang, Sizhe Huang, Bin Dong, Ying Jiang, Minfeng Tao, Jia Liu, Chuan You   +7 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Health care systems in transition: United Kingdom

, 1999
vii, 117 p.The Health Care Systems in Transition (HiT) profiles are country-based reports that provide an analytical description of each health care system and of reform initiatives in progress or under development.
European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe   +1 more
core   +1 more source

Comparison of Knowledge, Attitude, and Practices of Nursing Staff Regarding Cervical Cancer Screening at Various Levels of Health Care Facilities in Western India

Indian Journal of Community Medicine
Background: Cervical cancer is a public health problem, and nursing personnel are crucial for successful implementation of low-cost cervical cancer screening approaches in low-resource settings.
Rashmi Kaushal, Mamta Patel, Pankaj Bhardwaj, Manoj Gupta, Deepti Mathur, Girish Chandra Dash, Shashank Shekhar   +6 more
doaj   +1 more source

Access to primary and secondary health care services for people living with diabetes and lower-limb amputation during the COVID-19 pandemic in Lebanon: a qualitative study. [PDF]

BMC Health Serv Res, 2022
Chaiban L, Benyaich A, Yaacoub S, Rawi H, Truppa C, Bardus M.   +5 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Evaluation of clinical, etiological and antimicrobial resistance profile of pediatric urinary tract infections in a secondary health care centre. [PDF]

Afr Health Sci, 2021
Celep G, Özçelik HB.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source