Results 81 to 90 of about 1,508,558 (264)

The role of primary care in service provision for people with severe mental illness in the United Kingdom. [PDF]

, 2012
Severe mental illness is a serious and potentially life changing set of conditions. This paper describes and analyses patient characteristics and service usage over one year of a representative cohort of people with a diagnosis of severe mental illness ...
Siobhan Reilly, Lester, Helen, Mark Hann, Helen Lester, Irwin Nazareth, Lester, H, Lester Helen, Reeves, David, Planner, Claire, Hann Mark, David Reeves, Helen Lester (164644), Irwin Nazareth (144882), Reeves David, Planner, C, Nazareth Irwin, David Reeves (164641), Reilly, S, Siobhan Reilly (164633), Reilly Siobhan, Hann, M, Nazareth, Irwin, Claire Planner, Planner Claire, Reeves, D, Claire Planner (164636), Nazareth, I, Mark Hann (93547), Reilly, Siobhan, Hann, Mark   +29 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluation of a school-based health education program for urban Indigenous young people in Australia [PDF]

, 2014
: The aim of this study was to investigate the effectiveness of a school-based health promotion and education program in improving knowledge, attitudes, self-efficacy and behaviours of urban Indigenous young people regarding chronic disease and ...
Ware, Robert S., Nelson, Alison L., Nelson, Alison, Malseed, Claire, Claire Malseed, Alison Nelson, Robert Ware, Ware, Robert   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Young People's mental health service utilization

International Journal of Population Data Science
Objective This project aimed to uncover key factors that shape young people’s (YP) mental health care utilization. The Andersen’s Behavioral Model of Health Care Utilization was adapted in co-production, providing a framework for the predisposing ...
Corine Driessens, Peter W.F. Smith, Kim Markham-Jones, Fiona Lacey   +3 more
doaj   +1 more source

Beyond Antimalarial Stock-outs: Implications of Health Provider Compliance on Out-of-Pocket Expenditure during Care-Seeking for Fever in South East Tanzania. [PDF]

, 2013
To better understand how stock-outs of the first line antimalarial, Artemisinin-based Combination Therapy (ACT) and other non-compliant health worker behaviour, influence household expenditures during care-seeking for fever in the Ulanga District in ...
Rashid Khatib, Amuri, Baraka, de Savigny, Don, Mustafa Njozi, B. Amuri, R. Khatib, Manzi, Fatuma, F. Manzi, D. de Savigny, Gumi Abdallah, Njozi, Mustafa, I. Mikkelsen Lopez, Mikkelsen-Lopez, Inez, Abdallah, Gumi, Khatib, Rashid, Inez Mikkelsen-Lopez, Fatuma Manzi, M. Njozi, Tediosi, Fabrizio, G. Abdallah, Baraka Amuri, Fabrizio Tediosi, Don de Savigny   +22 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A review of certain recent advances in primary health care [PDF]

, 2014
A strong primary health care system is the keystone of health care and helps patients manage their health conditions in the community, whilst also providing disease prevention services.
Sammut, Mario R., Bezzina, Glorianne, Baldacchino, Marilyn, Scerri, Anne Marie   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Self-reported health and health care use in an ageing population in the Agincourt sub-district of rural South Africa [PDF]

, 2013
Background: South Africa is experiencing a demographic and epidemiological transition with an increase in population aged 50 years and older and rising prevalence of non-communicable diseases. This, coupled with high HIV and tuberculosis prevalence, puts
Kathleen Kahn, Benjamin Clark, Clark, B. (Benjamin), Tollman, Stephen, Margaret Thorogood, Tollman, Stephen,, Thorogood, Margaret, Clark, Benjamin, Gómez-Olivé, F. Xavier, Stephen Tollman, Kahn, Kathleen, Kahn, Kathleen,, Francesc Xavier Gómez-Olivé, Gómez-Olivé, Francesc Xavier   +13 more
core   +1 more source