Results 61 to 70 of about 1,508,558 (264)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Inclusion of edaphic predictors for enhancement of models to determine distribution of soil-transmitted helminths: the case of Zimbabwe

Parasites & Vectors, 2018
Background Reliable mapping of soil-transmitted helminth (STH) parasites requires rigorous statistical and machine learning algorithms capable of integrating the combined influence of several determinants to predict distributions.
Nicholas Midzi, Blessing Kavhu, Portia Manangazira, Isaac Phiri, Susan L. Mutambu, Cremants Tshuma, Moses J. Chimbari, Shungu Munyati, Stanely M. Midzi, Lincon Charimari, Anatoria Ncube, Masceline J. Mutsaka-Makuvaza, White Soko, Emmanuel Madzima, Gibson Hlerema, Joel Mbedzi, Gibson Mhlanga, Mhosisi Masocha   +17 more
doaj   +1 more source

A review of the effectiveness of smokefree strategies and interventions in secondary care settings [PDF]

, 2013
The aim of this review was to systematically review the effectiveness of smokefree strategies and interventions in secondary care settings (acute, maternity and mental health settings).
Murray, Rachael, Leonardi-Bee, Jo, MacDonald, Laura, O'Mara-Eves, Alison, Stansfield, Claire, Eadie, Douglas, Angus, Kathryn   +6 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Increasing the health literacy of learning disability and mental health nurses in physical care skills: a pre and post-test evaluation of a workshop on diabetes care [PDF]

, 2015
This paper presents the pre- and post-test results of the outcomes of a workshop designed to increase learning disability and mental health nurses’ knowledge and skill to undertake interventions for service users at risk of, or with a diagnosis of, type ...
Trotter, Fiona, Hemingway, Steve, Stephenson, John, Holdich, Phil, Hemingway, S, Clifton, Andrew, Trotter, F, Stephenson, J, Holdich, P, Clifton, A, Holdich, Phillip   +10 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A randomised, feasibility trial of a tele-health intervention for Acute Coronary Syndrome patients with depression (‘MoodCare’): study protocol. [PDF]

, 2011
Background Coronary heart disease (CHD) and depression are leading causes of disease burden globally and the two often co-exist. Depression is common after Myocardial Infarction (MI) and it has been estimated that 15-35% of patients experience depressive
Anna L Hawkes, Kathy Eadie, Hawkes, AL, Brian Oldenburg, Eadie, Kathy, Hollingsworth Bruce, Adrienne O'Neil, O'Neil, Adrienne, Bianca Chan, Taylor, C, Hawkes, Anna, Bruce Hollingsworth, Eadie, K, Chan Bianca, Michael Jelinek, John Atherton, Hawkes, A, Chan, Bianca, Atherton John, Sanderson, Kristy, O Neill, A, Hare, DL, Hare David L, David L Hare, O'Neil Adrienne, Eadie Kathy, Forbes, Andrew, Hollingsworth, B, Jelinek, M, Atherton, J, Atherton, John, Oldenburg, Brian, Hare, David L., Taylor C Barr, Taylor, CB, Jelinek, Michael, Hawkes Anna L, Kristy Sanderson, Hare, David, Hollingsworth, Bruce, Chan, B, Taylor, Craig, Forbes Andrew, Andrew Forbes, Sanderson, K, Oldenburg, B, Sanderson Kristy, Taylor, C. Barr, Oldenburg Brian, Taylor, Barr, C Barr Taylor, Forbes, A, Jelinek Michael, Hawkes, Anna L., O'Neil, A, Hare, D   +55 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Secondary prevention of arterial hypertension in primary health care

Zaporožskij Medicinskij Žurnal, 2012
Оn the example of «School of health» modern approaches to organization of treatment and prophylaxis help to population are proposed, which are directed on a primary link of heath protection system, on establishment of partnership between medical workers ...
V. L. Kurochka
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source